The Role of Alpha-MSH as a Modulator of Ocular Immunobiology Exemplifies Mechanistic Differences between Melanocortins and Steroids.
The Role of Alpha-MSH as a Modulator of Ocular Immunobiology Exemplifies Mechanistic Differences between Melanocortins and Steroids.
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DOI：
10.3109/09273948.2015.1092560
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发表时间：
2017-04
影响因子：
3.3
通讯作者：
Taylor AW
中科院分区：
文献类型：
--
作者：
Clemson CM;Yost J;Taylor AW
黑皮质素是一个高度保守的肽和受体家族，包括多种阿黑皮素原衍生肽和五种确定的黑皮质素受体。黑皮质素在维持免疫稳态和抑制炎症中具有重要作用。在健康的眼睛中，黑皮质素在预防炎症和维持免疫豁免方面起着核心作用。抗炎活性的中心介质是非类固醇生成黑皮质素肽α-黑素细胞刺激激素。在这篇综述中，我们总结了黑皮质素调节眼部免疫生物学的主要研究结果，特别是黑皮质素诱导免疫耐受和细胞保护的能力。黑皮质素具有治疗潜力，因为它们调节免疫的作用机制与类固醇的作用明显不同。
Melanocortins are a highly conserved family of peptides and receptors that includes multiple proopiomelanocortin-derived peptides and five defined melanocortin receptors. The melanocortins have an important role in maintaining immune homeostasis and in suppressing inflammation. Within the healthy eye, the melanocortins have a central role in preventing inflammation and maintaining immune privilege. A central mediator of the anti-inflammatory activity is the non-steroidogenic melanocortin peptide alpha-melanocyte stimulating hormone. In this review we summarize the major findings of melanocortin regulation of ocular immunobiology with particular interest in the ability of melanocortin to induce immune tolerance and cytoprotection. The melanocortins have therapeutic potential because their mechanisms of action in regulating immunity are distinctly different from the actions of steroids.