Estrogen quinones: reaction with propylamine.
Estrogen quinones: reaction with propylamine.
复制标题
雌激素醌：与丙胺反应。
DOI：
10.1021/tx00037a010
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发表时间：
1994
影响因子：
4.1
通讯作者：
Abul-Hajj,YJ
中科院分区：
文献类型：
--
作者：
Khasnis,D;Abul-Hajj,YJ
丙胺与2，3-雌酮邻苯二酚(2，3-EQ)和3，4-雌酮邻苯二酚(3，4-EQ)反应生成一个复杂的混合物。利用光谱技术对几种反应产物进行了分离和鉴定。用3，4-EQ观察到1，2-和1，6-Michael加成反应，其中4-羟基雌二醇是一种雌激素恶唑，紫罗兰色化合物是由一个雌激素邻氨基苯酚与丙胺的1，6-Michael加成产物缩合得到的亚氨基醌加合物。与3，4-EQ反应不同，2，3-EQ只发生1，2-Michael加成反应，生成2-羟基雌二醇、两个单亚氨基醌化合物和一个联亚氨基醌产物。
Reaction of propylamine with 2, 3-estrone o-quinone (2, 3-EQ) and 3, 4-estrone o-quinone (3, 4-EQ) gave a complex mixture of mostly unidentifiable products. Several reaction products were isolated and identified using spectroscopic techniques. With 3, 4-EQ, both 1, 2-and 1, 6-Michael addition reactions were observed in which 4-hydroxyestradiol, an estrogen oxazole, and a violet compound identified as the iminoquinone adduct that was obtained by condensation of one molecule of an estrogen o-aminophenol with the 1, 6-Michael addition product of propylamine to 3, 4-EQ were identified. Unlike reactions of 3, 4-EQ, only 1, 2-Michael addition reactions were observed with 2, 3-EQ leading to theformation of 2-hydroxyestradiol, two monoiminoquinone compounds, and a bisiminoquinone product.