Ankyrin repeat-containing proteins in Arabidopsis:: characterization of a novel and abundant group of genes coding ankyrin-transmembrane proteins
Ankyrin repeat-containing proteins in Arabidopsis:: characterization of a novel and abundant group of genes coding ankyrin-transmembrane proteins
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DOI：
10.1016/j.gene.2004.06.006
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发表时间：
2004-09-29
期刊：
影响因子：
3.5
通讯作者：
Vicient, CM
中科院分区：
文献类型：
--
作者：
Becerra, C;Jahrmann, T;Vicient, CM
锚蛋白重复序列广泛存在于真核生物、原核生物和一些病毒的蛋白质中，作为蛋白质间相互作用的结构域。我们已经搜索了所有存在于拟南芥蛋白质中的锚蛋白重复序列，并确定了它们的共有序列。我们共鉴定了105种蛋白质中存在的509个锚蛋白重复序列。含有锚蛋白重复序列的蛋白质可分为16组结构相似的蛋白质。最丰富的一组包含具有锚蛋白重复序列和跨膜结构域的蛋白质（AtANKTM）。序列相似性分析表明，这些蛋白质分为六个家庭。一些AtAnkTm基因被组织成串联阵列，而另一些则存在于拟南芥基因组的重复部分。分析了几个AtAnkTm基因的表达，即使在同一家族内也产生了各种各样的表达模式。这些蛋白质的可能功能进行了讨论，与其他物种中具有类似组织的蛋白质的已知功能进行比较。(C)2004 Elsevier B.V.保留所有权利。
Ankyrin repeats are present in a great variety of proteins of eukaryotes, prokaryotes and some viruses and they function as protein-protein interaction domains. We have search for all the ankyrin repeats present in Arabidopsis proteins and determined their consensus sequence. We identified a total of 509 ankyrin repeats present in 105 proteins. Ankyrin repeat containing proteins can be classified in 16 groups of structurally similar proteins. The most abundant group contains proteins with ankyrin repeats and transmembrane domains (AtANKTM). Sequence similarity analysis indicates that these proteins are divided in six families. Some of the AtAnkTm genes are organized in tandem arrays and others are present in duplicated parts of the Arabidopsis genome. The expression of several AtAnkTm genes was analyzed resulting in a wide variety of expression patterns even within the same family. The likely functions of these proteins are discussed in comparison with the known functions of proteins with similar organization in other species. (C) 2004 Elsevier B.V. All rights reserved.