Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine.
Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine.
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DOI：
10.1001/jama.1985.03360220053027
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发表时间：
1985-12
期刊：
影响因子：
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通讯作者：
D. Weber;W. Rutala;G. Samsa;J. E. Santimaw;S. Lemon
中科院分区：
文献类型：
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作者：
D. Weber;W. Rutala;G. Samsa;J. E. Santimaw;S. Lemon
Factors associated with lack of antibody response to the hepatitis B virus plasma vaccine were retrospectively evaluated by means of a logistic regression in 194 previously seronegative staff members of a community hospital. All subjects had received three doses of vaccine by intramuscular buttock injection using a 1-in, 23-gauge needle. Overall, only 55.7% of subjects developed detectable antibody to hepatitis B surface antigen in serum after immunization. The weight-height index served as a surrogate measure of obesity. Predictors of poor immunogenic response to hepatitis B vaccine included higher weight-height index, older age, and vaccine batch. Sex, race, timing of vaccine doses, and timing of postimmunization determination of antibody to hepatitis B surface antigen were not predictors of vaccine efficacy.
