Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs.
Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs.
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发表时间：
2006-10
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通讯作者：
V. Tandon;Rahul Gupta
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作者：
V. Tandon;Rahul Gupta
背景与药理学研究黄荆叶（VN）的药理活性及其作用机制。然而，没有人评估其作为标准抗炎治疗辅助剂的潜在作用。因此，本研究进行调查的乙醇叶提取物的VN Linn与标准的抗炎药物在口服（PO）的亚有效剂量的相互作用，以评估其作为一种辅助治疗的潜在作用。方法采用角叉菜胶致白化病大鼠足跖肿胀和棉球肉芽肿实验，研究亚有效剂量的黄荆叶提取物与标准药物的相互作用，以评价其潜在的辅助治疗作用。结果在角叉菜胶所致大鼠足跖肿胀和棉球肉芽肿模型中，亚有效剂量VN能显著增强保泰松和布洛芬的抗炎作用。VN对保泰松和布洛芬的抗炎活性有增强作用，提示VN可作为标准抗炎药的沿着治疗。
BACKGROUND & OBJECTIVES Leaves of Vitex negundo (VN) have been investigated for their antiinflammatory activity in past, including its mechanism of action. However, nobody has evaluated its potential role as an adjuvant with standard anti-inflammatory therapy. Therefore, the present study was undertaken to investigate interaction of ethanolic leaf extract of VN Linn with standard anti-inflammatory drugs in sub-effective doses per orally (PO) to evaluate its potential role as an adjuvant therapy. METHODS Carrageenin induced hind paw oedema and cotton pellet granuloma test in albino rats were employed to study interaction of Vitex negundo (VN) leaf extract with standard antiinflammatory drugs in sub-effective doses per orally to evaluate its potential role as an adjuvant therapy. RESULTS The sub-effective dose of VN potentiated anti-inflammatory activity of phenlbutazone and ibuprofen significantly in carrageenin induced hind paw oedema and cotton pellet granuloma models. INTERPRETATION & CONCLUSION The potentiation of anti-inflammatory activities phenlbutazone and ibuprofen by VN indicates that it may be useful as an adjuvant therapy along with standard antiinflammatory drugs.