Effects of age on across-participant variability of cortical reinstatement effects.
Effects of age on across-participant variability of cortical reinstatement effects.
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年龄对皮质恢复效果的跨参与者变异性的影响。
DOI：
10.1016/j.neuroimage.2019.02.005
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发表时间：
2019
期刊：
影响因子：
5.7
通讯作者：
Rugg,MichaelD
中科院分区：
文献类型：
--
作者：
Thakral,PrestonP;Wang,TracyH;Rugg,MichaelD
使用功能性磁共振成像数据，我们评估了内容选择性检索相关神经活动的跨参与者变异性是否随年龄而不同。我们通过采用跨参与者多体素模式分析（MVPA）来解决这个问题，预测年龄的增加与参与者之间检索相关皮质恢复的变异性降低相关。在研究过程中，24名年轻人和24名老年人观看了物体和具体的单词。测试项目包括学习的单词，学习对象的名称，和未学习的单词。参与者通过分别做出“记住”、“知道”和“新”的反应来判断这些项目是回忆的、熟悉的还是新的。MVPA进行属于“核心回忆网络”，背外侧前额叶皮层，和先前确定的内容选择体素集的每个区域。一个留一个参与者的分类方法，其中一个分类器进行了训练的参与者的子集和测试的数据从一个轭对举行的参与者。在研究阶段数据上训练分类器，以根据内容（图片或文字）区分研究试验。然后将分类器应用于测试阶段数据，以根据其学习条件区分所研究的测试词。在所有检查的区域中，分类器性能表现出对年龄的敏感性很小或没有敏感性，并且对于测试数据，其稳健性高于偶然性。因此，几乎没有证据支持这一假设，即跨参与者的变异性检索相关的皮质恢复不同的年龄。这些发现扩展了先前的证据，证明内容选择性皮质恢复是足够不变的，以支持跨健康成人寿命的跨参与者多体素分类。
Using functional magnetic resonance imaging data, we assessed whether across-participant variability of content-selective retrieval-related neural activity differs with age. We addressed this question by employing across-participant multi-voxel pattern analysis (MVPA), predicting that increasing age would be associated with reduced variability of retrieval-related cortical reinstatement across participants. During study, 24 young and 24 older participants viewed objects and concrete words. Test items comprised studied words, names of studied objects, and unstudied words. Participants judged whether the items were recollected, familiar, or new by making ‘Remember’, ‘Know’ and ‘New’ responses, respectively. MVPA was conducted on each region belonging to the ‘core recollection network’, dorsolateral prefrontal cortex, and a previously identified content-selective voxel set. A leave-one-participant-out classification approach was employed whereby a classifier was trained on a subset of participants and tested on the data from a yoked pair of held-out participants. Classifiers were trained on the study phase data to discriminate the study trials as a function of content (picture or word). The classifiers were then applied to the test phase data to discriminate studied test words according to their study condition. In all of the examined regions, classifier performance demonstrated little or no sensitivity to age and, for the test data, was robustly above chance. Thus, there was little evidence to support the hypothesis that across-participant variability of retrieval-related cortical reinstatement differs with age. The findings extend prior evidence by demonstrating that content-selective cortical reinstatement is sufficiently invariant to support across-participant multi-voxel classification across the healthy adult lifespan.