Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis
Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis
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DOI：
10.1016/j.clinph.2011.10.038
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发表时间：
2012-06-01
影响因子：
4.7
通讯作者：
Shimohama, Shun
中科院分区：
文献类型：
--
作者：
Imai, Tomihiro;Tsuda, Emiko;Shimohama, Shun
目的：阐明重症肌无力（MG）患者兴奋-收缩（E-C）耦合受损与抗兰尼碱受体（RyR）抗体之间的关系。方法：用针电极刺激三叉神经运动神经后，同时记录咬肌复合肌动作电位（CMAP）和下颌运动相关电位（MRP）。 E-C 耦合时间 (ECCT) 计算为 CMAP 和 MRP 之间的延迟差。对于每位患者，当对重复神经刺激的反应没有异常减少时，我们选择了代表性数据集。 26个数据集分为抗RyR阳性组（n = 12）和抗RyR阴性组（n = 14）。结果：抗RyR阳性组的咬肌ECCT（中位数、平均值、范围；3.6、3.8、3.0-5.9 ms）显着长于（p = 0.017）抗RyR阴性组（3.1， 3.1、2.7-4.0），尽管两组之间咬肌 CMAP 幅度和减少百分比没有显着差异。抗 RyR 阳性组的咬合力显着低于正常对照。结论：与 MG 中不存在抗体的情况相比，抗 RyR 抗体的存在与显着延长咬肌 ECCT 相关。意义：抗 RyR 抗体导致 MG 患者咬肌 E-C 耦合损伤。 (C) 2011 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: The aim of this study was to elucidate the relationship between the impairment of excitation-contraction (E-C) coupling and anti-ryanodine receptor (RyR) antibody in patients with myasthenia gravis (MG).Methods: Masseteric compound muscle action potential (CMAP) and mandibular movement-related potentials (MRPs) were recorded simultaneously after stimulating the trigeminal motor nerve with a needle electrode. The E-C coupling time (ECCT) was calculated as the latency difference between CMAP and MRP. For each patient, we selected a representative data set when there was no abnormal decrement in response to repetitive nerve stimulation. The 26 data sets were divided into an anti-RyR-positive group (n = 12) and an anti-RyR-negative group (n = 14).Results: Masseteric ECCT was significantly longer (p = 0.017) in anti-RyR-positive group (median, mean, range; 3.6, 3.8, 3.0-5.9 ms) than in anti-RyR-negative group (3.1, 3.1, 2.7-4.0) although there were no significant differences in masseteric CMAP amplitude and % decrement between the two groups. The bite force was significantly lower in anti-RyR-positive group than in normal controls.Conclusions: Presence of anti-RyR antibodies is associated with significantly prolonged masseteric ECCT compared to absence of the antibodies in MG.Significance: Anti-RyR antibody contributes to E-C coupling impairment in the masseter muscle in patients with MG. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.