Midlife Fruit and Vegetable Consumption and Risk of Dementia in Later Life in Swedish Twins
Midlife Fruit and Vegetable Consumption and Risk of Dementia in Later Life in Swedish Twins
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DOI：
10.1097/jgp.0b013e3181c65250
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发表时间：
2010-05-01
影响因子：
7.2
通讯作者：
Gatz, Margaret
中科院分区：
文献类型：
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作者：
Hughes, Tiffany F.;Andel, Ross;Gatz, Margaret
目的：饮食可能与痴呆和阿尔茨海默病（AD）的风险有关。作者研究了中年水果和蔬菜的摄入量与所有类型的痴呆症和 AD 风险之间的关联。方法：参与者是瑞典双胞胎登记处的 3,779 名成员，他们在认知筛查和痴呆症全面临床评估前大约 30 年完成了饮食调查问卷，作为瑞典双胞胎痴呆症研究 (HARMONY) 的一部分。参与者中，有 355 名双胞胎被诊断患有痴呆症。其中，81对双胞胎在痴呆症方面不一致（50对在AD方面不一致）。使用广义估计方程对整个样本的数据进行逻辑回归分析，以调整双胞胎的相关性，并使用条件逻辑回归对双胞胎控制设计进行分析。结果：在完全调整的模型中，与不吃或很少吃水果和蔬菜相比，饮食中含有中等或大量水果和蔬菜与痴呆和 AD 风险降低相关。在女性和心绞痛患者中观察到了这种效应。在双胞胎对照分析中发现了类似但不显着的比值比。结论：研究结果表明，摄入更多的水果和蔬菜可能会降低患痴呆症的风险，尤其是女性和中年患有心绞痛的患者。 （《美国老年精神病学杂志》2010 年；18：413-420）
Objective: Diet may be associated with risk of dementia and Alzheimer disease (AD). The authors examined the association between fruit and vegetable consumption in midlife and risk for all types of dementia and AD. Methods: Participants were 3,779 members of the Swedish Twin Registry who completed a diet questionnaire approximately 30 years before cognitive screening and full clinical evaluation for dementia as part of the study of dementia in Swedish Twins (HARMONY) study. Among the participants, 355 twins were diagnosed with dementia. Among these, 81 twin pairs were discordant for dementia (50 discordant for AD). Data were analyzed with logistic regression for the entire sample using generalized estimating equations to adjust for relatedness of twins and with conditional logistic regression for the co-twin control design. Results: In fully adjusted models, a medium or great proportion of fruits and vegetables in the diet, compared with no or small, was associated with a decreased risk of dementia and AD. This effect was observed among women and those with angina. Similar, but nonsignificant, odds ratios were found in the co-twin control analyses. Conclusion: The findings suggest that higher fruit and vegetable consumption may reduce the risk of dementia, especially among women and those with angina pectoris in midlife. (Am J Geriatr Psychiatry 2010; 18: 413-420)