CHANGES IN THE CONNECTIVE-TISSUE OF CORPUS AND CERVIX UTERI DURING RIPENING AND LABOR IN TERM PREGNANCY
CHANGES IN THE CONNECTIVE-TISSUE OF CORPUS AND CERVIX UTERI DURING RIPENING AND LABOR IN TERM PREGNANCY
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DOI：
10.1111/j.1471-0528.1989.tb03196.x
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发表时间：
1989-10-01
期刊：
影响因子：
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通讯作者：
MALMSTROM, A
中科院分区：
文献类型：
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作者：
GRANSTROM, L;EKMAN, G;MALMSTROM, A
对7例非妊娠妇女和14例妊娠妇女的子宫颈和子宫体结缔组织的组成进行了研究，以检查子宫颈和子宫颈结缔组织的自发性宫颈成熟和分娩引起的变化。在宫颈和子宫体中的主要发现是胶原蛋白浓度的大幅度（40-60%）降低。通过胃蛋白酶消化获得的胶原蛋白可提取性增加了两倍，表明胶原蛋白原纤维的组织发生了变化。这种重组过程也可以通过用人工DNP-肽底物证明的胶原分解活性的大幅增加来证明。硫酸化糖胺聚糖的浓度在妊娠妇女中低于非妊娠妇女。结果表明，子宫颈和子宫体都含有大量的结缔组织成分（胶原蛋白，硫酸化糖胺聚糖和透明质酸），并且在成熟过程中，结缔组织成分的重建发生在两个部位。这表明宫颈状态反映了子宫肌层的状态。
The composition of the connective tissue of human cervix and corpus uteri was studied in tissue specimens from seven non-pregnant women and 14 pregnant women, delivered at term by section, to examine spontaneous cervical ripening and labour-induced changes in both the uterine and the cervical connective tissue. The main finding in both the cervix and the corpus was a large (40-60%) decrease of the collagen concentration. The collagen extractability, obtained by pepsin digestion, was increased twofold, suggesting a change of the organization of the collagen fibrils. This reorganization process could also be demonstrated by a large increase of the collangenolytic activity demonstrated with an artificial DNP-peptide substrate. The concentrations of sulphated glycosaminoglycans was lower in pregnant women than in non-pregnant women. The results show that both the cervix and the corpus uteri contain substantial amounts of connective tissue components (collagen, sulphated glycosaminoglycans and hyaluronic acid) and that during ripening, reconstruction of the connective tissue components occurs in both sites. This indicates that the cervical state reflects that of the myometrium.