Factors regulating trophoblast invasion
Factors regulating trophoblast invasion
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DOI：
10.1159/000101734
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Bischof, Paul
中科院分区：
文献类型：
--
作者：
Cohen, Marie;Bischof, Paul
植入人体是独一无二的。这种独特性的特点是在母体一侧的自发和大量的子宫内膜蜕膜化和胚胎侧的几乎无限的侵入潜力。人类胚胎表现出内在的侵入潜力，这使得它们几乎可以植入除了子宫内膜之外的任何地方，因为它可以保护自己免受植入。因此，人体植入仅在称为植入窗口的有限时间段内是可能的。这篇简短的综述强调了研究滋养细胞侵入子宫内膜作为人类着床模型的重要性。细胞滋养层细胞（CTB）可以很容易地从早期妊娠法律的流产中分离出来，并在体外培养时保持其侵袭性行为。该模型表明，基质金属蛋白酶（MMPs）是由CTB产生的，并有助于其侵袭行为。胚胎植入和肿瘤侵袭使用这些相同的生物化学介质进行侵袭。然而，与肿瘤侵袭相反，滋养细胞侵袭在时间和空间上都是有限的：它发生在妊娠的前三个月，并且侵袭不超过子宫肌层的近端三分之一。调节MMP表达的因素来自母体和胎儿。
Implantation in the human is unique. This uniqueness is characterized on the maternal side by a spontaneous and massive decidualization of the endometrium and on the embryonic side by an almost unlimited invasive potential. Human embryos express an intrinsic invasive potential, which allows them to implant almost anywhere except in the endometrium because it protects itself from implantation. Human implantation is thus only possible during a limited period of time known as the implantation window. This mini review stresses the importance of studying trophoblast invasion into the endometrium as a model for human implantation. Cytotrophoblastic cells (CTB) can easily be isolated from first-trimester legal abortions and retain their invasive behavior when cultured in vitro. This model shows that matrix metalloproteinases ( MMPs) are produced by CTB and are instrumental to their invasive behavior. Embryo implantation and tumor invasion use these same biochemical mediators for invasion. However, in contrast to tumor invasion, trophoblast invasion is limited both in time and space: it occurs during the first trimester of pregnancy and invasion does not go beyond the proximal third of the myometrium. Factors regulating MMP expression are of maternal and fetal origin.