Polarity of bacterial magnetotaxis is controlled by aerotaxis through a common sensory pathway
Polarity of bacterial magnetotaxis is controlled by aerotaxis through a common sensory pathway
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DOI：
10.1038/ncomms6398
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发表时间：
2014-11-01
影响因子：
16.6
通讯作者：
Schueler, Dirk
中科院分区：
文献类型：
--
作者：
Popp, Felix;Armitage, Judith P.;Schueler, Dirk
大多数能动细菌通过调节随机定向的游泳片段的长度来在外部化学刺激的梯度内导航。趋磁细菌的特征是细胞内铁磁纳米颗粒链及其感知地磁场的能力，据信这有助于定向运动，但在行为和分子水平上还没有得到很好的理解。在这里，我们发现，细胞的磁gryphiswaldense意外显示游泳极性，这取决于趋氧信号转导通过其四个趋化操纵子（cheOp1）。细胞在叠加在氧气梯度上的磁场中生长，导致一种逐渐遗传的游泳偏向，其中一个细胞极领先，这样整个种群的总体游泳方向可以通过氧气浓度的变化而逆转。这些发现清楚地表明，有一个直接的分子之间的联系，趋气传感和决定趋磁极性，通过感觉通路，CheOp1。
Most motile bacteria navigate within gradients of external chemical stimuli by regulating the length of randomly oriented swimming episodes. Magnetotactic bacteria are characterized by chains of intracellular ferromagnetic nanoparticles and their ability to sense the geomagnetic field, which is believed to facilitate directed motion, but is not well understood at the behavioural and molecular level. Here, we show that cells of Magnetospirillum gryphiswaldense unexpectedly display swimming polarity that depends on aerotactic signal transduction through one of its four chemotaxis operons (cheOp1). Growth of cells in magnetic fields superimposed on oxygen gradients results in a gradual inherited bias of swimming runs with one of the cell poles leading, such that the resulting overall swimming direction of entire populations can be reversed by changes in oxygen concentration. These findings clearly show that there is a direct molecular link between aerotactic sensing and the determination of magnetotactic polarity, through the sensory pathway, CheOp1.