Interplay of Broccoli/Broccoli Sprout Bioactives with Gut Microbiota in Reducing Inflammation in Inflammatory Bowel Diseases.
Interplay of Broccoli/Broccoli Sprout Bioactives with Gut Microbiota in Reducing Inflammation in Inflammatory Bowel Diseases.
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DOI：
10.1016/j.jnutbio.2022.109238
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发表时间：
2022-11
期刊：
影响因子：
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通讯作者：
Johanna M. Holman;Molly Hurd;P. Moses;G. Mawe;Zhang Tao;S. Ishaq;Yanyan Li
中科院分区：
文献类型：
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作者：
Johanna M. Holman;Molly Hurd;P. Moses;G. Mawe;Zhang Tao;S. Ishaq;Yanyan Li
炎症性肠病（IBD）是以胃肠道炎症为特征的慢性、复发性和衰弱性病症，其中一些可导致更全身性的并发症，并且可包括自身免疫功能障碍、肠道中微生物群落的分类和功能结构的变化以及人的日常生活中的复杂负担。与许多基于慢性炎症的疾病一样，对IBD的研究指出了多因素的起源，涉及人的生活方式，免疫系统，相关微生物群落和环境条件等因素。治疗目前仅作为姑息治疗存在，并寻求通过减少炎症和允许尽可能多地恢复体内平衡来破坏症状的反馈回路。已经探索了各种抗炎的选择，这篇评论的重点是使用饮食作为改善肠道健康的替代手段。具体来说，我们强调了十字花科蔬菜中萝卜硫素在调节炎症和修饰微生物群落中的作用之间的联系，并打破了它们在IBD中的作用。
Inflammatory Bowel Diseases (IBD) are chronic, reoccurring, and debilitating conditions characterized by inflammation in the gastrointestinal tract, some of which can lead to more systemic complications and can include autoimmune dysfunction, a change in the taxonomic and functional structure of microbial communities in the gut, and complicated burdens in a person's daily life. Like many diseases based in chronic inflammation, research on IBD has pointed towards a multifactorial origin involving factors of the person's lifestyle, immune system, associated microbial communities, and environmental conditions. Treatment currently exists only as palliative care, and seeks to disrupt the feedback loop of symptoms by reducing inflammation and allowing as much of a return to homeostasis as possible. Various anti-inflammatory options have been explored, and this review focuses on the use of diet as an alternative means of improving gut health. Specifically, we highlight the connection between the role of sulforaphane from cruciferous vegetables in regulating inflammation and in modifying microbial communities, and to break down the role they play in IBD.