15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1α expression in human colon cancer cells.
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1α expression in human colon cancer cells.
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DOI：
10.1002/cam4.222
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发表时间：
2014-06
期刊：
影响因子：
4
通讯作者：
Shureiqi, Imad
中科院分区：
文献类型：
--
作者：
Wu, Yuanqing;Mao, Fei;Zuo, Xiangsheng;Moussalli, Micheline J.;Elias, Elias;Xu, Weiguo;Shureiqi, Imad
The expression of 15-lipoxygenase-1 (15-LOX-1) is downregulated in colon cancer and other major cancers, and 15-LOX-1 reexpression in cancer cells suppresses colonic tumorigenesis. Various lines of evidence indicate that 15-LOX-1 expression suppresses premetastatic stages of colonic tumorigenesis; nevertheless, the role of 15-LOX-1 loss of expression in cancer epithelial cells in metastases continues to be debated. Hypoxia, a common feature of the cancer microenvironment, promotes prometastatic mechanisms such as the upregulation of hypoxia-inducible factor (HIF)-1α, a transcriptional master regulator that enhances cancer cell metastatic potential, angiogenesis, and tumor cell invasion and migration. We have, therefore, tested whether restoring 15-LOX-1 in colon cancer cells affects cancer cells' hypoxia response that promotes metastasis. We found that 15-LOX-1 reexpression in HCT116, HT29LMM, and LoVo colon cancer cells inhibited survival, vascular endothelial growth factor (VEGF) expression, angiogenesis, cancer cell migration and invasion, and HIF-1α protein expression and stability under hypoxia. These findings demonstrate that 15-LOX-1 expression loss in cancer cells promotes metastasis and that therapeutically targeting ubiquitous 15-LOX-1 loss in cancer cells has the potential to suppress metastasis.
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影响因子：
45.3
作者：
Giantonio, Bruce J.;Catalano, Paul J.;Benson, Al B., III
通讯作者：
Benson, Al B., III
影响因子：
168.9
作者：
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通讯作者：
Moore, Nicola
影响因子：
11.2
作者：
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通讯作者：
Hedley, David W.
DOI：
10.1016/j.plefa.2006.01.009
发表时间：
2006-04-01
影响因子：
3
作者：
Jiang, WG;Watkins, G;Mansel, RE
通讯作者：
Mansel, RE
影响因子：
8
作者：
Kang, X.;Li, J.;Cheng, J.
通讯作者：
Cheng, J.