Primary hepatic carcinosarcoma
Primary hepatic carcinosarcoma
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DOI：
10.1016/s1499-3872(11)60015-5
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Ozbakir, Omer
中科院分区：
文献类型：
--
作者：
Celikbilek, Mehmet;Deniz, Kemal;Ozbakir, Omer
背景：原发性肝癌肉瘤是一种罕见的恶性肿瘤，含有癌性和肉瘤性成分的密切混合物。报告的危险因素，流行病学和发病机制的肿瘤，以及在其treatment.METHOD的经验：我们提出了一个情况下，原发性癌肉瘤的肝脏在一个69岁的男子谁抱怨右下腹疼痛和体重减轻了两个months.Results：磁共振成像显示一个14 x12厘米的质量段7-8和4肝静脉侵犯。超声引导活检显示骨样组织无成骨细胞镶边。血管结构伴随着骨样组织。患者在诊断为血管瘤后接受了手术。术中冷冻切片显示癌肉瘤与骨肉瘤和胆管细胞癌components. CONCLUSION：术前诊断这种罕见的原发性肝脏恶性肿瘤可能是困难的活检，由于肿瘤内异质性高度成熟的地区的骨肉瘤成分可能会导致误诊的化生骨组织。这种罕见的实体的临床病理特征进行了讨论。
BACKGROUND: Primary hepatic carcinosarcoma is a rare malignant tumor containing an intimate mixture of carcinomatous and sarcomatous elements. Reports on risk factors, epidemiology, and pathogenesis of the tumor as well as the experience in its treatment are limited.METHOD: We present a case of primary carcinosarcoma of the liver in a 69-year-old man who complained of right hypochondrial pain and weight loss for two months.RESULTS: Magnetic resonance imaging revealed a 14x12 cm mass in segments 7-8 and 4 of the liver with vena hepatica invasion. An ultrasonography-guided biopsy showed osteoid tissue without osteoblastic rimming. Vascular structures accompanied the osteoid tissue. The patient underwent surgery after a diagnosis of hemangioma. Intraoperative frozen sections revealed a carcinosarcoma associated with an osteosarcoma and cholangiocellular carcinoma components.CONCLUSIONS: Preoperative diagnosis of this rare primary hepatic malignant tumor may be difficult by biopsy owing to intra tumoral heterogeneity Highly mature areas of the osteosatcomatous component may lead to misdiagnosis of metaplastic bone tissue. Clinicopathologic features of this rare entity are discussed.