The essential tension: opposed reactions in bacterial two-component regulatory systems.
The essential tension: opposed reactions in bacterial two-component regulatory systems.
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DOI：
10.1016/0966-842x(93)90007-e
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发表时间：
1993-11-01
影响因子：
15.9
通讯作者：
Silhavy, T J
中科院分区：
文献类型：
--
作者：
Russo, F D;Silhavy, T J
在许多不同的细菌中，几种感觉反应功能是由类似设计的系统控制的。大多数由两种蛋白质组成，其中一种蛋白质调节另一种蛋白质的磷酸化以响应环境刺激。调节是通过平衡相互对立的磷酸化和去磷酸化反应来实现的。值得注意的是，这样的系统可以产生一个信号，其强度与任一组分的浓度无关。
In many different bacteria several sensory-response functions are controlled by systems of similar design. Most consist of two proteins, one of which regulates the phosphorylation of the other in response to an environmental stimulus. Regulation is achieved by balancing opposed phosphorylation and dephosphorylation reactions against each other. Remarkably, such a system can generate a signal whose strength is independent of the concentration of either component.