Emergence of New Non-Clonal Group 258 High-Risk Clones among Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Isolates, France
Emergence of New Non-Clonal Group 258 High-Risk Clones among Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Isolates, France
复制标题
DOI：
10.3201/eid2606.191517
复制
发表时间：
2020-06-01
影响因子：
11.8
通讯作者：
Dortet, Laurent
中科院分区：
文献类型：
--
作者：
Bonnin, Remy A.;Jousset, Agnes B.;Dortet, Laurent
据报告，产肺炎克雷伯菌碳青霉烯酶（KPC-Kp）分离株的全球传播是由1种克隆复合物（即，克隆组[CG] 258，包括序列类型[ST] 258和512）。我们于2018年对法国所有KPC-Kp分离株进行了全基因组测序和流行病学分析，发现ST 147、ST 307、ST 231和ST 383的新成功高风险克隆现在是bla（KPC）基因的主要驱动因素。bla（KPC）基因主要由Tn 4401 a和Tn 4401 d结构以及一个新的非Tn 4401元件携带。我们的流行病学调查表明，这些非CG 258 KPC-Kp分离株在法国的出现与这些克隆从葡萄牙传播有关。因此，KPC-Kp流行病学在欧洲发生了变化，至少在西欧的几个非KPC流行国家，如法国和葡萄牙，其中CG 258不是最流行的克隆。
The worldwide spread of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) isolates was reported to be caused by dissemination of 1 clonal complex (i.e., clonal group [CG] 258, which includes sequence types [STs] 258 and 512). We conducted whole-genome sequencing and epidemiologic analysis of all KPC-Kp isolates in France in 2018 and found that new successful high-risk clones of ST147, ST307, ST231, and ST383 are now the main drivers of bla(KPC) genes. The bla(KPC) genes were mostly carried by Tn4401a and Tn4401d structures and a new non-Tn4401 element. Our epidemiologic investigations showed that the emergence of these non-CG258 KPC-Kp isolates in France was linked to dissemination of these clones from Portugal. Thus, KPC-Kp epidemiology has changed in Europe, at least in several non-KPC-endemic countries of western Europe, such as France and Portugal, where CG258 is not the most prevalent clone.