MRI-BASED HIPPOCAMPAL VOLUME MEASUREMENTS IN EPILEPSY
MRI-BASED HIPPOCAMPAL VOLUME MEASUREMENTS IN EPILEPSY
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DOI：
10.1111/j.1528-1157.1994.tb05986.x
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发表时间：
1994-01-01
期刊：
影响因子：
5.6
通讯作者：
JACK, CR
中科院分区：
文献类型：
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作者：
JACK, CR
在脑形态计量学的研究中，人们普遍认为正常和异常的脑结构与功能之间存在着一定的关系。形态结构的一个描述符是体积。海马形态学异常，包括单侧或双侧体积损失，已知发生在癫痫、阿尔茨海默病和某些遗忘综合征中。精确的定量应该提高对任何生物系统在正常功能和疾病中的作用的理解。基于磁共振（MR）的海马体积测量的目的是精确定量，确定正常范围，并确定生物变量和畸变之间的关联，在这个体积参数。体积测量在海马大小的估计中引入了一定程度的精确度，这不是简单地通过视觉检查一组MR图像就可以获得的，因此能够进行基于统计的假设检验。为了使用磁共振成像（MRI）进行准确的海马体积测量，必须注意整个操作的两个主要组成部分，即MR图像采集和图像处理。
In the study of brain morphometry, it is accepted that a relationship exists between brain structure and function, both normal and abnormal. One descriptor of morphometric structure is volume. Abnormalities in hippocampal morphology, including unilateral or bilateral volume loss, are known to occur in epilepsy, Alzheimer's disease, and in certain amnestic syndromes. Precise quantitation should improve understanding of the role of any biologic system in normal function and in disease. The objectives of magnetic resonance (MR)-based hippocampal volume measurements are precise quantitation, identification of a normal range, and identification of the association between biologic variables and aberrations in this volumetric parameter. Volumetric measures introduce a level of precision in the estimation of hippocampal size that is not available simply by visually inspecting a set of MR images, thus enabling statistically based hypothesis testing. To produce accurate hippocampal volume measurements with magnetic resonance imaging (MRI), attention must be directed to the two major components of the operation as a whole, MR image acquisition and image processing.