Early Histamine Release and Death Due to Endotoxin
Early Histamine Release and Death Due to Endotoxin
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组胺早期释放和内毒素导致的死亡
DOI：
10.3181/00379727-137-35690
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发表时间：
1971
影响因子：
--
通讯作者：
M. Heiffer
中科院分区：
文献类型：
--
作者：
J. Vick;Ben Mehlman;M. Heiffer
静脉注射致死剂量的E.大肠杆菌内毒素注入麻醉狗体内，引起动脉血压急剧下降，血浆组胺急剧增加，循环血小板急剧减少。组胺的增加，如动脉压的下降，发生在给予致死剂量的内毒素后30-60秒内。相反，亚致死剂量的内毒素仅使动脉血压适度降低，血浆组胺水平无显著升高，循环血小板略有下降。在这项研究中，血浆组胺的增加总是与致死性结局相关。在任何情况下，均未发生组胺升高导致的死亡。结果表明，早期和显着增加组胺似乎遵循注射致死剂量的内毒素，它是非常可能的，这种早期释放的组胺是以某种方式参与心血管变化和这种形式的休克在狗的最终致死性。缓激肽、血清素和儿茶酚胺可能参与其中。
Summary The intravenous injection of a lethal dose of E. coli endotoxin into anesthetized dogs produces a precipitous fall in arterial blood pressure, a sharp increase in plasma histamine and an abrupt decrease in circulating platelets. The increase in histamine, like the fall in arterial pressure, occurs within 30-60 sec following the administration of a lethal dose of endotoxin. In contrast, sublethal doses of endotoxin produce only modest decreases in arterial blood pressure, no significant elevation in plasma histamine levels, and a slight fall in circulating platelets. In this study an increase in plasma histamine was always associated with a lethal outcome. In no instance was there death with no prior elevation in histamine. Results indicate that an early and marked increase in histamine seems to follow the injection of a lethal dose of endotoxin, and it is highly probable that this early release of histamine is in some way involved in both the cardiovascular changes and the ultimate lethality of this form of shock in the dog. The possible involvement of bradykinin, serotonin, and the catecholamines is indicated.