A GENERAL-MODEL FOR THE TRANSMEMBRANE PROTEINS OF HIV AND OTHER RETROVIRUSES
A GENERAL-MODEL FOR THE TRANSMEMBRANE PROTEINS OF HIV AND OTHER RETROVIRUSES
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DOI：
10.1089/aid.1989.5.431
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发表时间：
1989-08-01
影响因子：
1.5
通讯作者：
MONTELARO, RC
中科院分区：
文献类型：
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作者：
GALLAHER, WR;BALL, JM;MONTELARO, RC
从流感病毒跨膜蛋白HA2的已知结构出发，提出了人类免疫缺陷病毒(HIV)跨膜蛋白的假设模型。该模型与预测蛋白质结构的计算机算法以及由序列同源性、定点突变、肽类似物、免疫化学或其他生物手段确定的TM蛋白质的已知性质是一致的。它适用于各种总分子量差异很大的逆转录病毒TM蛋白。
A hypothetical model of the transmembrane (TM) protein of human immunodeficiency virus (HIV) is proposed that is derived from the known structure of the influenza TM protein HA2. This model is consistent with computer algorithms of predicted protein structure and with known properties of TM proteins determined by sequence homology, site-directed mutations, peptide analogs, immunochemistry, or other biologic means. It is applicable to a wide variety of retroviral TM proteins differing widely in overall molecular weight.