Early Parenting Intervention and Adverse Family Environments Affect Neural Function in Middle Childhood
Early Parenting Intervention and Adverse Family Environments Affect Neural Function in Middle Childhood
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DOI：
10.1016/j.biopsych.2018.09.020
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发表时间：
2019-02-15
影响因子：
10.6
通讯作者：
Dozier, Mary
中科院分区：
文献类型：
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作者：
Bick, Johanna;Palmwood, Erin N.;Dozier, Mary
背景：越来越多的研究指出早期不良经历对大脑发育的负面影响。一个悬而未决的问题涉及早期干预在多大程度上可以使高危儿童的大脑发育轨迹正常化。我们在早期育儿计划“依恋和生物行为追赶”(ABC) 的随机临床试验中对此进行了测试，该计划向儿童保护服务机构监测虐待情况的父母和婴儿提供。方法：家庭在儿童 2.5 岁或以下时参加了随机临床试验。养育子女和家庭逆境是在基线时进行测量的。对儿童进行纵向随访，并在儿童年满 8 岁时通过电生理学方法测量静息大脑活动（n = 106）。对分配到实验干预组 (ABC)、对照干预组和在后续评估中招募的低风险对照组 (n = 76) 的儿童的频谱功率进行量化和比较。结果：较高的早期家庭逆境与表明儿童中期皮质延迟/不成熟的电生理学特征相关，基于较低频段（θ，4-6 Hz 和低 α，6-9 Hz）的相对较大功率和较低频段的功率。更高频段（高 alpha，9-12 Hz）。分配到 ABC 的儿童比分配到对照干预的儿童表现出相对更大的高频功率（β，12-20 Hz）。 ABC 中的 Beta 功效与低风险对照组没有差异。结论：虐待风险和家庭逆境会影响儿童中期大脑成熟的指标。早期养育计划可以支持童年中期神经功能更加规范的模式。
BACKGROUND: Growing work points to the negative impact of early adverse experiences on the developing brain. An outstanding question concerns the extent to which early intervention can normalize trajectories of brain development in at-risk children. We tested this within the context of a randomized clinical trial of an early parenting program, the Attachment and Biobehavioral Catch-up (ABC), delivered to parents and infants monitored for maltreatment by Child Protective Services.METHODS: Families participated in the randomized clinical trial when children were 2.5 years of age or younger. Parenting and home adversity was measured at baseline. Children were followed longitudinally, and resting brain activity was measured electrophysiologically (n = 106) when children reached 8 years of age. Spectral power was quantified and compared across children assigned to the experimental intervention (ABC), a control intervention, and a low-risk comparison group (n = 76) recruited at the follow-up assessment.RESULTS: Higher early home adversity was associated with electrophysiological profiles indicative of cortical delays/immaturity in middle childhood, based on relatively greater power in lower frequency bands (theta, 4-6 Hz, and low alpha, 6-9 Hz) and lower power in a higher frequency band (high alpha, 9-12 Hz). Children assigned to ABC showed relatively greater high-frequency power (beta, 12-20 Hz) than children assigned to the control intervention. Beta power in the ABC did not differ from that of the low-risk comparison group.CONCLUSIONS: Maltreatment risk and home adversity can affect indicators of middle childhood brain maturation. Early parenting programs can support more normative patterns of neural function during middle childhood.