Elevated Serum Ubiquitin Carboxy-Terminal Hydrolase L1 Is Associated with Abnormal Blood-Brain Barrier Function after Traumatic Brain Injury
Elevated Serum Ubiquitin Carboxy-Terminal Hydrolase L1 Is Associated with Abnormal Blood-Brain Barrier Function after Traumatic Brain Injury
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DOI：
10.1089/neu.2010.1653
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发表时间：
2011-12-01
影响因子：
4.2
通讯作者：
Bazarian, Jeffrey J.
中科院分区：
文献类型：
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作者：
Blyth, Brian J.;Farahvar, Arash;Bazarian, Jeffrey J.
血清S100 B升高准确反映血脑屏障（BBB）损伤。由于S100 B也存在于外周组织中，因此这种蛋白质的释放可能不是中枢神经系统（CNS）损伤的特异性。泛素C末端水解酶1（UCHL 1）和磷酸化神经丝重链（pNF-H）仅在神经元中发现，但它们与BBB功能障碍的关系尚未确定。本研究的目的是确定血清UCHL 1和pNF-H作为创伤性脑损伤（TBI）后BBB完整性指标的准确性，并将其与S100 B进行比较。我们对16例中重度TBI患者进行了前瞻性研究（格拉斯哥昏迷量表[GCS]评分
Serum S100B elevations accurately reflect blood-brain barrier (BBB) damage. Because S100B is also present in peripheral tissues, release of this protein may not be specific to central nervous system (CNS) injury. Ubiquitin C-terminal hydrolase 1 (UCHL1), and phosphorylated neurofilament heavy chain (pNF-H) are found exclusively in neurons, but their relationship to BBB dysfunction has not been determined. The objective of this study was to determine the accuracy of serum UCHL1 and pNF-H as measures of BBB integrity after traumatic brain injury (TBI), to and compare them to S100B. We performed a prospective study of 16 patients with moderate to severe TBI (Glasgow Coma Scale [GCS] score