Ultrastructural analysis of rat brain tissue following systemic kainate administration.
Ultrastructural analysis of rat brain tissue following systemic kainate administration.
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全身红藻氨酸施用后大鼠脑组织的超微结构分析。
DOI：
10.1007/978-1-4684-7971-3_17
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发表时间：
1986
影响因子：
--
通讯作者：
F. Seitelberger
中科院分区：
文献类型：
--
作者：
H. Lassmann;H. Baran;U. Petsche;K. Kitz;G. Sperk;O. Hornykiewicz;F. Seitelberger
实验性癫痫模型中的形态学研究主要集中在神经细胞的病理组织学变化（Schwob等人，1980; Ben-Ari等人，1981年）。虽然很明显，神经元是兴奋性毒素作用的主要靶点，但最近的证据表明，除了直接的神经毒性外，其他发病机制在癫痫后脑损伤的发展中起着重要作用。因此，有趣的是注意到，红藻氨酸（KA）诱导的癫痫发作后的不可逆神经病理学变化不仅涉及神经细胞，而且涉及神经胶质、髓鞘和血管（Sperk等人，1983年）。在我们目前的研究中，我们描述了一系列的形态学事件在大鼠的边缘系统，全身注射KA。我们的研究结果表明，细胞毒性脑水肿和随后的局灶性缺血在不可逆性癫痫引起的脑损伤的发病机制中起着核心作用。
Morphological studies in models of experimental epilepsy have mainly focused on pathohistological changes of nerve cells (Schwob et al., 1980; Ben-Ari et al., 1981). Although it is evident, that neurons are the primary target in the action of excitotoxins, recent evidence suggests that besides direct neurotoxicity other pathogenetic mechanisms play an important role in the development of postepileptic brain damage. It is thus interesting to note, that irreversible neuropathological changes following kainic acid (KA) induced seizures not only involve nerve cells, but also glia, myelin sheaths and blood vessels (Sperk et al., 1983). In our present study we describe the sequence of morphological events in the limbic system of rats, systemically injected with KA. Our findings indicate that cytotoxic brain edema and subsequent focal ischemia plays a central role in the pathogenesis of irreversible seizure induced brain lesions.