Self-administration of 5-iodo-A-85380, a beta2-selective nicotinic receptor ligand, by operantly trained rats.
Self-administration of 5-iodo-A-85380, a beta2-selective nicotinic receptor ligand, by operantly trained rats.
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由经过操作训练的大鼠自行施用 5-iodo-A-85380（一种 β2 选择性烟碱受体配体）。
DOI：
10.1097/00001756-200308060-00020
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发表时间：
2003
期刊：
影响因子：
1.7
通讯作者：
London,EdytheD
中科院分区：
文献类型：
--
作者：
Liu,Xiu;Koren,AndreiO;Yee,SusanK;Pechnick,RobertN;Poland,RussellE;London,EdytheD
人们普遍认为，尼古丁是烟草烟雾中促进烟草依赖的活性成分。尼古丁与尼古丁乙酰胆碱受体（nAChR）的几种亚型相互作用。在脑中，它主要靶向含有β2和α4亚基组合以及仅由α7亚基组成的nAChR。本研究测试了经操作训练的大鼠是否会自我给予对含β2（即非α7）nAChR具有活性的配体。训练雄性Sprague-Dawley大鼠进行杠杆按压以进行静脉内可卡因自我给药。可卡因洗脱2周后，大鼠每天1小时操作性接触5-碘-A-85380（5IA），一种β2-选择性nAChR配体。大鼠迅速形成稳定水平的5IA自我给药行为（单位剂量= 5 nmol/kg/输注）。这一发现表明，与含β2的nAChR相互作用，而不直接参与α7受体，可以产生强化，从而可以支持自我给药行为。
It is widely accepted that nicotine is the active ingredient of tobacco smoke that promotes tobacco dependence. Nicotine interacts with several subtypes of nicotinic acetylcholine receptors (nAChRs). In brain, it primarily targets nAChRs that contain β2 and α4 subunits in combination and those composed of solely α7 subunits. The present study tested whether operantly trained rats would self-administer a ligand active at β2-containing (ie not α7) nAChRs. Male Sprague-Dawley rats were trained to lever press for iv cocaine self-administration. After 2 weeks of cocaine washout, rats were given operant access to 5-iodo-A-85380 (5IA), a β2-selective nAChR ligand, in daily 1 h sessions. The rats rapidly developed a stable level of 5IA self-administration behavior (unit dose= 5 nmol/kg/infusion). This finding suggests that interaction with β2-containing nAChRs, without direct involvement of α7 receptors, can produce reinforcement and thereby can support self-administration behavior.