Age-dependent chromosomal distribution of male-biased genes in Drosophila
Age-dependent chromosomal distribution of male-biased genes in Drosophila
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DOI：
10.1101/gr.107334.110
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发表时间：
2010-11-01
期刊：
影响因子：
7
通讯作者：
Long, Manyuan
中科院分区：
文献类型：
--
作者：
Zhang, Yong E.;Vibranovski, Maria D.;Long, Manyuan
我们研究了果蝇中通过DNA中间体（DNA水平）复制或通过新生形成的新雄性偏倚基因的染色体位置与年龄分布之间的相关性。我们的全基因组分析揭示了过量的年轻x连锁男性偏见基因。x连锁的男性偏倚基因的比例随着时间的推移而减少，导致男性偏倚基因的常染色体过量。雄性偏倚基因的x连锁富集和常染色体富集之间的切换也存在于伪黑鲈新x染色体上的两种蛋白质编码基因和黑鲈的microRNA基因的分布中。这些观察结果表明，雄性偏倚基因的进化比之前检测到的X -> A基因的一步转运和雄性偏倚基因在常染色体上的富集更为复杂。我们检测到的模式表明，多种进化力量的相互作用，如减数分裂性染色体失活（MSCI）、更快的x效应和雄性生殖系的性拮抗，可能在不同的进化时间尺度上塑造了雄性偏倚基因的染色体分布。[补充材料可在http://www.genome.org.]网站上获得
We investigated the correlation between the chromosomal location and age distribution of new male-biased genes formed by duplications via DNA intermediates (DNA-level) or by de novo origination in Drosophila. Our genome-wide analysis revealed an excess of young X-linked male-biased genes. The proportion of X-linked male-biased genes then diminishes through time, leading to an autosomal excess of male-biased genes. The switch between X-linked and autosomal enrichment of male-biased genes was also present in the distribution of both protein-coding genes on the D. pseudoobscura neo-X chromosome and microRNA genes of D. melanogaster. These observations revealed that the evolution of male-biased genes is more complicated than the previously detected one-step X -> A gene traffic and the enrichment of the male-biased genes on autosomes. The pattern we detected suggests that the interaction of various evolutionary forces such as the meiotic sex chromosome inactivation (MSCI), faster-X effect, and sexual antagonism in the male germline might have shaped the chromosomal distribution of male-biased genes on different evolutionary time scales. [Supplemental material is available online at http://www.genome.org.]