Hepatitis E virus infection prevalence among selected populations in Iowa
Hepatitis E virus infection prevalence among selected populations in Iowa
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DOI：
10.1016/s1386-6532(99)00037-2
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发表时间：
1999-09-01
影响因子：
8.8
通讯作者：
Naides, SJ
中科院分区：
文献类型：
--
作者：
Karetnyi, YV;Gilchrist, MJR;Naides, SJ
背景：戊型肝炎是气候炎热的发展中地区流行的一种肠道传染病。美国报告了一例内源性HEV感染。最近，在爱荷华州从猪身上分离出了hev样病毒。养猪生产是爱荷华州的一个主要产业，在工业和家庭农场经营中及其周围，人类有可能接触到猪。目的：研究目的是确定爱荷华州的个体是否暴露于HEV。研究设计：确定爱荷华州4个选定人群中抗hev抗体的流行情况。收集204例非甲、非乙、非丙型肝炎（non-A- c）患者的血清；自然资源部工作人员87名；1989年无偿献血332人；1998年有111名志愿献血者。所有血清均采用ELISA检测抗人HEV IgM和Ige，经肽中和试验证实阳性。结果：非a、非b、非c型肝炎患者（4.9%）和爱荷华州DNR健康现场工作人员（5.7%）的抗hev IgG抗体阳性率均高于1998年采集的正常献血者（P < 0.05）。结论：人类HEV或一种HEV样病毒在爱荷华州地理区域传播。职业暴露于野生动物和家畜粪便环境源或患有不明原因肝炎的高危人群HEV抗体血清阳性率升高。(C) 1999 Elsevier Science B.V.版权所有
Background: HEV causes an enteric infectious disease endemic in developing areas with hot climate. A case of endogenous HEV infection has been reported in the US. Recently, HEV-like virus was isolated from swine in Iowa. Swine production is a major industry in Iowa with the potential for human exposure to swine in and around industrial and Family farm operations. Objective: The study objective was to determine whether individuals in Iowa are exposed to HEV. Study design: Anti-HEV antibody prevalence in four selected Iowa populations was determined. Sera were collected from 204 patients with non-A, non-B, non-C hepatitis (non-A-C); 87 staff members of the Department of Natural Resources (DRN); 332 volunteer blood donors in 1989; and 111 volunteer blood donors in 1998. All sera were tested for anti-human HEV IgM and Ige by ELISA with confirmation of positivity by a peptide neutralization test. Results: Both the patients with non-A, non-B, non-C hepatitis (4.9%) and the healthy field workers from the Iowa DNR (5.7%) showed significantly higher prevalence of anti-HEV IgG antibodies compared to normal blood donor sera collected in 1998 (P < 0.05). Conclusions: Human HEV or a HEV-like agent circulates in the Iowa geographical area. At-risk human populations with occupational exposure to wild animals and environmental sources of domestic animal wastes or with unexplained hepatitis have increased seroprevalence of HEV antibodies. (C) 1999 Elsevier Science B.V. All rights reserved.