Correlation of neuron-specific enolase and S1OOB with histological cerebral damage in fetal sheep after severe asphyxia
Correlation of neuron-specific enolase and S1OOB with histological cerebral damage in fetal sheep after severe asphyxia
复制标题
DOI：
10.1016/j.brainres.2004.05.061
复制
发表时间：
2004-08-20
期刊：
影响因子：
2.9
通讯作者：
Murata, Y
中科院分区：
文献类型：
--
作者：
Fujii, EY;Kozuki, M;Murata, Y
用16只胎羊通过脐带阻断造成实验性脑损伤，并对其中7只胎羊进行了神经元特异性烯醇化酶（NSE）和S100 B与脑损伤程度的相关性研究。斯皮尔曼氏检验显示损伤程度与损伤后2h血清NSE（p = 0.016）和S100 B（p = 0.018）有显著相关性。这些结果表明，他们代表了潜在的有用的标志物，用于检测脑缺血损伤后的早期阶段。(C)2004 Elsevier B.V.保留所有权利。
Experimental brain damage was induced in 16 fetal sheep by umbilical cord occlusion, and the correlation of neuron-specific enolase (NSE) or S100B with the damage grade was investigated in seven fetuses. Significant correlations of damage degree with NSE (p = 0.016) and S100B (p = 0.018) in serum 2 h after insult were shown by Spearman's test. These findings suggest that they represent potentially useful markers for detecting brain damage at early stage after ischemic insult. (C) 2004 Elsevier B.V. All rights reserved.