Rotavirus Vaccine Take in Infants Is Associated With Secretor Status
Rotavirus Vaccine Take in Infants Is Associated With Secretor Status
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DOI：
10.1093/infdis/jiy573
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发表时间：
2019-03-01
影响因子：
6.4
通讯作者：
Parashar, Umesh D.
中科院分区：
文献类型：
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作者：
Armah, George E.;Cortese, Margaret M.;Parashar, Umesh D.
轮状病毒通过组织血型抗原(HBGA)与肠道细胞结合，这种抗原也可在唾液中检测到。我们评估了166名加纳婴儿在疫苗试验中接种2-3剂G1P[8]轮状病毒疫苗后的抗轮状病毒免疫球蛋白A血清转换情况，方法是从4.1岁时收集的唾液中检测HBGA状态。只有分泌者状态与血清转换有关：分泌者血清转换率为41%，非分泌者为13%；相对危险度为3.2(95%可信区间为1.2-8.1；P=0.016)。Lewis抗原和唾液抗原血型均与血清转换无关。基于HBGA，接种任何特定轮状病毒疫苗的可能性在不同人群中可能不同。非分泌型婴儿在接种口服G1P[8]轮状病毒疫苗后出现血清抗体反应的可能性是分泌型轮状病毒疫苗的三分之一左右。根据组织血型抗原的不同，不同人群接种任何特定轮状病毒疫苗的可能性可能不同。
Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion (vaccine take) among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of take for any particular rotavirus vaccine may differ across populations based on HBGAs.Infants who are nonsecretors were about one-third as likely to have a serum antibody response after receiving oral G1P[8] rotavirus vaccine than secretors. Likelihood of take for any particular rotavirus vaccine may differ across populations based on histo-blood group antigens.