Morphometric Analysis of Podocyte Foot Process Effacement in IgA Nephropathy and Its Association with Proteinuria
Morphometric Analysis of Podocyte Foot Process Effacement in IgA Nephropathy and Its Association with Proteinuria
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DOI：
10.3109/01913121003648402
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发表时间：
2010-08-01
影响因子：
1
通讯作者：
Lim, Beom Jin
中科院分区：
文献类型：
--
作者：
Choi, Song Yi;Suh, Kwang Sun;Lim, Beom Jin
足细胞足突的消失是许多蛋白尿肾小球肾炎的常见现象。IgA肾病的基本征象是血尿，但蛋白尿也经常发生。作者测量了100例IgA肾病伴蛋白尿的足突消退程度，并将其与蛋白尿量相关联。肾病蛋白尿组足突消退的程度大于亚肾病蛋白尿组或对照组。足突消退程度与蛋白尿呈正相关。本研究表明IgA肾病患者蛋白尿与足突消退密切相关。
The effacement of podocyte foot processes is a well-known phenomenon occurring in many glomerulonephritides with proteinuria. The fundamental sign of IgA nephropathy is hematuria, but proteinuria also frequently occurs. The authors measured the extent of foot process effacement in 100 IgA nephropathy cases with proteinuria and correlated it with the amount of proteinuria. The extent of foot process effacement was greater in the nephrotic proteinuria group than in the subnephrotic proteinuria or control groups. The degree of foot process effacement was positively correlated with proteinuria. This study demonstrates that proteinuria in IgA nephropathy is closely related to foot process effacement.