RESUSCITATION FROM BUPIVACAINE-INDUCED ASYSTOLE IN RATS - COMPARISON OF DIFFERENT CARDIOACTIVE DRUGS
RESUSCITATION FROM BUPIVACAINE-INDUCED ASYSTOLE IN RATS - COMPARISON OF DIFFERENT CARDIOACTIVE DRUGS
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DOI：
10.1097/00000539-199506000-00011
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发表时间：
1995-06-01
影响因子：
5.7
通讯作者：
ROSENBERG, PH
中科院分区：
文献类型：
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作者：
HEAVNER, JE;PITKANEN, MT;ROSENBERG, PH
本研究的目的是比较布比卡因诱导心搏停止后不同心脏活性药物复苏尝试的成功率。测试了盐水、氨力农（1 mg/kg）、多巴胺（5 μ g/kg）、去甲肾上腺素（2 μ g/kg）、肾上腺素（10 μ g/kg）或异丙肾上腺素（1 μ g/kg）。将60只大鼠分配到6个治疗组（n = 10/组），轻度麻醉（0.5%氟烷，70%N2O），麻痹（多沙库铵），并静脉内给予4 mg布比卡因。kg（-1）。min（-1）至心搏停止。5秒后，以30秒的间隔给予多达3次治疗药物剂量。然后根据需要进行外部心脏按摩。给予去甲肾上腺素或肾上腺素的所有动物均恢复了自主心跳。在1只生理盐水-1只多巴胺治疗组、1只异丙肾上腺素治疗组和3只氨力农治疗组动物中未恢复。去甲肾上腺素组复苏成功率最高，氨力农组最低（P <0.05）。复苏后，肾上腺素和异丙肾上腺素处理的动物室性心律失常的发生率显著高于其他动物（P <0.05）。去甲肾上腺素成功复苏后20 min内心律紊乱消失。氨力农在治疗布比卡因引起的心搏停止方面并不比生理盐水更有效。具有心脏刺激剂（β（1）-受体激动剂）和外周血管收缩剂（α（1）-受体激动剂）活性的药物如去甲肾上腺素可以是治疗布比卡因诱导的心搏停止的选择药物。
The objective of this study was to compare the success of resuscitation attempts with different cardioactive drugs after bupivacaine-induced asystole. Saline, amrinone (1 mg/kg), dopamine (5 (mu g/kg), norepinephrine (2 mu g/kg), epinephrine (10 mu g/kg), or isoproterenol (1 mu g/kg) were tested. Sixty rats assigned to six treatment groups (n = 10/group) were Lightly anesthetized (0.5% halothane, 70% N2O), paralyzed (doxacurium), and given bupivacaine intravenously at 4 mg . kg(-1). min(-1) until asystole. Five seconds later up to three treatment drug doses were given at 30-s intervals. Then external cardiac massage was instituted as needed. Spontaneous heartbeat was restored in all animals given norepinephrine or epinephrine. It was not restored in one saline-one dopamine-treated, one isoproterenol-treated and three amrinone-treated animals. The highest (best) arbitrary scores for overall resuscitation success were achieved with norepinephrine and the lowest with amrinone (P < 0.05). The incidence of ventricular arrhythmias after resuscitation was significantly higher (P < 0.05) in epinephrine- and isoproterenol-treated animals versus other animals. Cardiac rhythm disturbance disappeared within 20 min after successful resuscitation with norepinephrine. Amrinone was no more effective than saline in treating bupivacaine-induced asystole. A drug such as norepinephrine, which has both cardiostimulator (beta(1)-receptor agonist) and peripheral vasoconstrictor (alpha(1)-receptor agonist) activity, may be the drug of choice for treating asystole induced by bupivacaine.