Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin
Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin
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DOI：
10.1248/bpb.21.1072
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发表时间：
1998-10-01
影响因子：
2
通讯作者：
Takido, M
中科院分区：
文献类型：
--
作者：
Yasukawa, K;Akihisa, T;Takido, M
在米糠和γ-谷维素的甲醇提取物中观察到对12 - O - 十四酰基佛波醇 - 13 - 乙酸酯（TPA）诱导的小鼠炎症有抑制活性。米糠的活性成分阿魏酸谷甾醇、阿魏酸24 - 甲基胆固醇、阿魏酸环阿屯醇和阿魏酸24 - 亚甲基环阿屯醇显著抑制TPA诱导的小鼠炎症。这些化合物对TPA诱导的炎症的50%抑制剂量为0.2 - 0.3毫克/耳。此外，阿魏酸环阿屯醇显著抑制TPA在7,12 - 二甲基苯并[a]蒽引发的小鼠中的促肿瘤作用。
Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of rice bran and gamma-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.2-0.3 mg/ear, Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7,12-dimethylbenz[a] anthracene-initiated mice.