Dietary Mg and/or K restriction enhances paraquat toxicity in rats
Dietary Mg and/or K restriction enhances paraquat toxicity in rats
复制标题
饮食中镁和/或钾的限制会增强大鼠的百草枯毒性
DOI：
10.1007/s002040050526
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发表时间：
1998
影响因子：
6.1
通讯作者：
N. Harada
中科院分区：
文献类型：
--
作者：
K. Minakata;O. Suzuki;S. Saito;N. Harada
摘要为明确预防百草枯中毒所必需的矿物质，研究了限制矿物质摄入的效果。由于ODS大鼠不能像人类那样合成维生素C，因此被选为实验动物。大鼠喂食含125 ppm PQ的矿物质充足或限制性饲料。矿物质充足的饮食是基于美国营养研究所-76，限制饮食是数量的一半。测定了PQ中毒发病日、饲养试验期间体重的变化以及两种急性时相反应蛋白半胱氨酸蛋白酶抑制剂和α1-蛋白酶抑制剂的变化。测试的矿物质分为三类：I，大量需要，钙，钾，钠，镁; II，中度需要，锰，铁，锌，铜;和III，微量需要，铬和硒，分别。用镁限制饮食喂养的大鼠表现出严重的中毒，但用钾限制饮食喂养的大鼠表现出轻度中毒。没有观察到明显的影响，通过限制其他矿物质。Mg和K的限制具有协同效应。
Abstract Effect of mineral restriction was studied to clarify which mineral in the diet is most indispensable in preventing paraquat (PQ) toxicosis. ODS rats were chosen as the experimental animal owing to the inability to synthesize vitamin C similarly to humans. Rats were fed with either mineral-adequate or restricted diets dosed with 125 ppm PQ. The mineral-adequate diet was based on the American Institute of Nutrition-76, and the restricted diet was one-half the amounts. Measurements were made on the onset day of PQ toxicosis, body weight changes during the feeding experiment, and changes of two acute phase reactant proteins – cysteine proteinase inhibitor and α1-proteinase inhibitor. The minerals tested were divided into three classes: I, largely needed, Ca, K, Na, and Mg; II, moderately needed, Mn, Fe, Zn, and Cu; and III, minutely needed, Cr and Se, respectively. Rats fed with a Mg-restricted diet showed a severe toxicosis but those with a K-restricted diet, a mild toxicosis. No appreciable effect was observed by restriction of other minerals. A synergistic effect was observed in the restriction of Mg and K.
百草枯对肺部的保护作用依赖于钙。
DOI：
10.1152/jappl.1992.72.2.498
发表时间：
1992
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Barnard,JW;Womack,WA;Smith,SM;Engerson,TD;Taylor,AE
通讯作者：
Taylor,AE