Characterization of antihypertensive therapy by whole-day blood pressure monitoring.
Characterization of antihypertensive therapy by whole-day blood pressure monitoring.
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通过全天血压监测来表征抗高血压治疗。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
J. Lipson
中科院分区：
文献类型：
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作者：
Michael A. Weber;Deanna G. Cheung;W. Graettinger;J. Lipson
全天动态监测用于诊断高血压和判断对治疗的反应。我们在使用钙通道阻滞剂盐酸地尔硫卓的抗高血压试验中评估了这两种特性。用传统血压计测量，接受地尔硫卓治疗的患者收缩压和舒张压显著下降，而接受安慰剂治疗的患者没有一致的变化。通过自动监测，药物的给药还可以在一天内均匀地降低收缩压和舒张压。15例地尔硫卓治疗的患者被细分为临床诊断为高血压的患者（24小时平均舒张压，大于或等于90 mm Hg; n = 9）和24小时血压不符合此标准的患者（n = 6）。地尔硫卓治疗使高血压患者的平均全天血压降低18/13 mm Hg，而其他患者仅降低0/1 mm Hg。因此，全天血压监测通过记录疗效和治疗持续时间来加强抗高血压试验。此外，它提高了高血压的诊断，从而确定了哪些患者的治疗似乎是合理的。
Whole-day ambulatory monitoring is used for diagnosing hypertension and for judging response to treatment. We evaluated both of these properties in an antihypertensive trial with the calcium channel blocker diltiazem hydrochloride. Measured by a conventional sphygmomanometer, systolic and diastolic blood pressures fell significantly in patients who received diltiazem, whereas no consistent changes occurred in those who received placebo. Administration of the drug also decreased systolic and diastolic blood pressures evenly throughout the day, as determined by automated monitoring. The 15 diltiazem-treated patients were subdivided into those whose clinically diagnosed hypertension was confirmed by pretreatment blood pressure monitoring (24-hour average diastolic blood pressure, greater than or equal to 90 mm Hg; n = 9) and those whose 24-hour blood pressures failed to meet this criterion (n = 6). Diltiazem therapy decreased average whole-day blood pressures by 18/13 mm Hg in the hypertensives but by only 0/1 mm Hg in the others. Thus, whole-day blood pressure monitoring strengthens antihypertensive trials by documenting efficacy and duration of treatment. In addition, it enhances the diagnosis of hypertension, thereby identifying those patients in whom treatment seems justified.