Effect of implanting fibrin sealant with ropivacaine on pain after laparoscopic cholecystectomy
Effect of implanting fibrin sealant with ropivacaine on pain after laparoscopic cholecystectomy
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DOI：
10.3748/wjg.15.5851
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发表时间：
2009-12-14
影响因子：
4.3
通讯作者：
Yu, Ze-Li
中科院分区：
文献类型：
--
作者：
Fu, Jian-Zhu;Li, Jie;Yu, Ze-Li
目的：目的探讨纤维蛋白粘合剂复合罗哌卡因缓释剂用于腹腔镜胆囊切除术（LC）后胆囊床植入镇痛的安全性和有效性。（美国麻醉医师协会身体状况为I或11，并接受LC）随机分为三组：A组（纤维蛋白粘合剂胆囊床植入组）、B组（纤维蛋白粘合剂携带罗哌卡因胆囊床植入组）、C组（生理盐水胆囊床植入组）。结果：腹腔镜胆囊切除术后81.7%的患者出现内脏痛，50%的患者出现顶骨痛，26.7%的患者出现肩部痛。B组患者内脏疼痛明显少于其他组（P < 0.05），该组仅1例患者发生肩部疼痛。结论：LC术后内脏疼痛明显，纤维蛋白粘合剂联合罗哌卡因胆囊床植入可有效控制LC术后内脏疼痛。(C)2009 WJG出版社和百世登。All rights reserved.
AIM: To investigate the safety and efficacy of implanting fibrin sealant with sustained-release ropivacaine in the gallbladder bed for pain after laparoscopic cholecystectomy (LC).METHODS: Sixty patients (American Society of Anesthesiologists physical status was I or 11 and underwent LC) were randomly divided into three equal groups: group A (implantation of fibrin sealant in the gallbladder bed), group B (implantation of fibrin sealant carrying ropivacaine in the gallbladder bed), and group C (normal saline in the gallbladder bed). Postoperative pain was evaluated, and pain relief was assessed by visual analog scale (VAS) scoring.RESULTS: The findings showed that 81.7% of patients had visceral pain, 50% experienced parietal, and 26.7% reported shoulder pain after LC. Visceral pain was significantly less in group B patients than in the other groups (P < 0.05), and only one patient in this group experienced shoulder pain. The mean VAS score in group B patients was lower than that in the other groups.CONCLUSION: Visceral pain is prominent after LC and can be effectively controlled by implanting fibrin sealant combined with ropivacaine in the gallbladder bed. (C) 2009 The WJG Press and Baishideng. All rights reserved.