Nonvoiding Activity of the Guinea Pig Bladder
Nonvoiding Activity of the Guinea Pig Bladder
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DOI：
10.1016/j.juro.2011.03.123
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发表时间：
2011-08-01
影响因子：
6.6
通讯作者：
de Wachter, Stefan G.
中科院分区：
文献类型：
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作者：
Biallosterski, Bart T.;van Koeveringe, Gommert A.;de Wachter, Stefan G.
目的：逼尿肌非排尿性收缩发生在高达70%的健康人。这些收缩在具有病理性逼尿肌功能的患者中增加，并且可能与传入活动相关。我们研究了非排尿收缩在乌拉坦麻醉豚鼠膀胱和研究的填充率和intravesicalvolume.Materials和方法的效果：共14只豚鼠麻醉，并进行膀胱导管在圆顶。在6只豚鼠中，膀胱灌注是连续的，并使用两种生理充盈速率，包括25 μ l/min（0.75 HD）和50 μ l/min（1.5 HD）。另8只豚鼠进行等容膀胱测压，方法是递增充盈膀胱，记录低、中、高膀胱内容积。随着膀胱充盈，收缩的频率和幅度增加。确定了不同的阶段。排尿后立即没有观察到非排尿性收缩，随后是连续活动，首先是小收缩，然后是小收缩和大收缩。小的非排尿性收缩的频率呈阶段性，而大的非排尿性收缩的频率缓慢增加或保持稳定。非排尿性收缩的频率和幅度在更快的充盈率和更高的膀胱内volume.Conclusions：非排尿性收缩存在于麻醉豚鼠。在正常生理条件下，它们的振幅和频率随着充盈率和膀胱内容积的增加而增加。小的和大的非排尿性收缩在频率模式上不同，并且发生在不同的膀胱充盈期。这可能说明不同的传入功能在膀胱充盈，这可能是重要的了解膀胱病理。
Purpose: Detrusor nonvoiding contractions occur in up to 70% of healthy individuals. These contractions increase in those with pathological detrusor function and may be associated with afferent activity. We examined nonvoiding contractions in the urethane anesthetized guinea pig bladder and studied the effect of filling rate and intravesical volume.Materials and Methods: A total of 14 guinea pigs were anesthetized and underwent bladder catheterization at the dome. In 6 guinea pigs bladder infusion was continuous and 2 physiological filling rates were used, including 25 (0.75 HD) and 50 mu l per minute (1.5 HD). In another 8 guinea pigs isovolumetric cystometry was done by filling the bladder incrementally and recording at low, medium and high intravesical volume.Results: Nonvoiding contractions were apparent in all animals. Contractions increased in frequency and amplitude as the bladder filled. Different phases were identified. Immediately after a void no nonvoiding contractions were observed, followed by continuous activity, first with small contractions, and later with small and large contractions. Small nonvoiding contractions showed a phasic pattern in frequency while the frequency of large nonvoiding contractions slowly increased or remained stable. The frequency and amplitude of nonvoiding contractions were higher at a faster filling rate and a higher intravesical volume.Conclusions: Nonvoiding contractions are present in the anesthetized guinea pig. Under normal physiological conditions they increase in amplitude and frequency with the increase in the filling rate and in intravesical volume. Small and large nonvoiding contractions differ in frequency pattern and occur at different bladder filling periods. This may illustrate different afferents functioning during bladder filling, which could be important for understanding bladder pathology.