SULFHYDRYL COMPOUNDS MAY MEDIATE GASTRIC CYTOPROTECTION
SULFHYDRYL COMPOUNDS MAY MEDIATE GASTRIC CYTOPROTECTION
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DOI：
10.1126/science.7280691
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
FRANKEL, PW
中科院分区：
文献类型：
--
作者：
SZABO, S;TRIER, JS;FRANKEL, PW
乙醇诱导出血性胃糜烂，并导致大鼠胃粘膜中非蛋白SH化合物浓度呈剂量依赖性降低。含SH的药物保护大鼠免受乙醇诱导的胃糜烂，而SH阻断剂抵消前列腺素F2 β的粘膜细胞保护作用。内源性非蛋白SH化合物可能介导甘草素诱导的胃细胞保护作用。SH药物可能具有预防或治疗出血性胃糜烂的潜力。
Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein SH compounds in rat gastric mucosa. SH-containing drugs protect rats from ethanol-induced gastric erosions, whereas SH blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2.beta.. Endogenous nonprotein SH compounds may mediate prostaglandin-induced gastric cytoprotection. SH drugs may have potential for preventing or treating hemorrhagic gastric erosions.