Nanoscale Insights into Ion-Beam Cancer Therapy

Nanoscale Insights into Ion-Beam Cancer Therapy
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DOI:
10.1007/978-3-319-43030-0
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发表时间:
2017
期刊:
--
影响因子:
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通讯作者:
A. Solov'yov
A. Solov'yov
中科院分区:
其他
文献类型:
--
作者:
A. Solov'yov

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的 两 主要 产品 的 电离 辐射 在 生物 组织 是 电子 和 根的大量的二次电子是由DNA附近的分子电离产生的,平均能量约为10 eV。这些低能电子可以通过解离电子附着和其他机制导致DNA链断裂。这些现象的建模需要,一方面,一个明确的量子描述的电子的目标分子(通常是一个亚单位的DNA链),另一方面,一个现实的帐户的DNA环境。本章回顾了理论和计算方法,使我们能够研究电子动力学(激发,电离,运输和本地化)系统的生物利益。
The two main products of ionizing radiation in biological tissues are electrons and radicals. The numerous secondary electrons are generated by ionisation in the molecules in the vicinity of DNA and are produced with a mean energy about 10 eV. These low-energy electrons can lead to DNA strand breaks via dissociative electron attachment and other mechanisms. The modelling of these phenomena requires, on the one hand, an explicit quantum description of the electrons of the target molecule (typically, a subunit of a DNA strand), and on the other hand, a realistic account of the DNA environment. This chapter reviews theoretical and computational approaches that have allowed us to study electron dynamics (excitation, ionization, transport and localization) in systems of biological interest.