How should we assess the safety of IVF technologies?
How should we assess the safety of IVF technologies?
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DOI：
10.1016/j.rbmo.2013.09.006
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发表时间：
2013-12-01
影响因子：
4
通讯作者：
Kimber, Susan J.
中科院分区：
文献类型：
--
作者：
Brison, Daniel R.;Roberts, Stephen A.;Kimber, Susan J.
临床试管受精治疗是在30多年前通过爱德华兹和斯特普托以及世界各地的其他团队的开创性工作而建立的，现在被认为是常规治疗。然而，科技进步的速度意味着试管受精从业者现在可以获得越来越多的新的侵入性技术。例子很多，但包括：延长胚胎培养，发展包括生长因子的培养液，基因筛选的发展，延时技术的使用，以及胚胎和卵母细胞玻璃化的出现。与此同时，更广泛的科学和医学进步正在提高我们对辅助生殖技术在胚胎发育、基因表达和基因组印记以及健康和疾病的发育起源等领域的潜在影响的认识。最近提出的一种评估试管受精新技术的范例包括发展啮齿动物和大型动物等动物模型，利用人类配子和胚胎捐赠进行临床前研究，进行试管受精的前瞻性临床试验，以及最后对试管受精儿童进行后续研究。在这篇文章中，我们描述了解决这一途径的关键领域的努力，即使用人类配子/胚胎的临床前研究和对辅助生殖儿童健康的长期后续研究。(C)2013，爱思唯尔有限公司出版的《生殖健康有限公司》。版权所有。
Clinical IVF treatment was established over 30 years ago through pioneering work by Edwards and Steptoe and other teams around the world and is now considered routine treatment. However, the pace of scientific and technological advances means that IVF practitioners can now access an increasing array of new and invasive technologies. The examples are many but include: extended embryo culture, development of media to include growth factors, developments in genetic screening, use of time-lapse technology and the advent of vitrification of embryos and oocytes. In parallel, wider scientific and medical advances are raising our awareness of the potential impact of assisted reproduction technology on areas such as embryonic development, gene expression and genomic imprinting and the developmental origins of health and disease. A recently suggested paradigm for assessing new technologies in IVF includes development in animal models such as rodents and large animals, preclinical research with human gametes and embryos donated to research, prospective clinical trials in IVF and, finally, follow-up studies of IVF children. In this paper, we describe efforts to address key areas of this pathway, namely preclinical research using human gametes/embryos and long-term, follow-up studies of the health of assisted reproduction children. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.