Prediction of creatinine clearance from serum creatinine in patients with rheumatoid arthritis: Comparison of six formulae and one nomogram
Prediction of creatinine clearance from serum creatinine in patients with rheumatoid arthritis: Comparison of six formulae and one nomogram
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DOI：
10.1007/s100670050006
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发表时间：
2000-01-01
影响因子：
3.4
通讯作者：
Schattenkirchner, M
中科院分区：
文献类型：
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作者：
Anders, HJ;Rihl, M;Schattenkirchner, M
肾小球滤过率的测定对类风湿关节炎（RA）患者的治疗具有重要意义。然而，测定内生肌酐清除率（Clcr）从24小时尿液收集是一个不可靠的和耗时的程序。因此，我们在38例RA患者和20例对照组中测试了6个方程和1个列线图预测血清肌酐（Scr）的准确性。对照组（r = 0.83-0.94）和RA组（r = 0.51-0.69）的各项指标均呈正相关。该方法没有高估类风湿关节炎的Clcr。在RA组中，Cockcroft发表的简单公式[Clcr =（（140 -年龄）x体重）/（72 x Scr），x 0.85（女性）]显示出与测量的Clcr的最佳相关性。在RA中，Cockroft公式可以可靠地用于从Scr预测Clcr。
The estimation of glomerular filtration rate is important for the medical treatment of patients with rheumatoid arthritis (RA). However, the determination of endogenous creatinine clearance (Clcr) from a 24-h urine collection is an unreliable and time-consuming procedure. We therefore tested the accuracy of six equations and one nomogram for the prediction of (Clcr from serum creatinine (Scr) in 38 patients with RA and 20 controls. A positive correlation was found for all methods in the controls (r = 0.83-0.94) and RA patients (r = 0.51-0.69). The methods did not overestimate Clcr in RA. In the RA group the simple formula published by Cockcroft [Clcr = ((140 - age) x body weight)/(72 x Scr), x 0.85 for females] showed the best correlation with the measured Clcr. In RA the Cockroft formula can reliably be used to predict Clcr from Scr.