YPD™, PombePD™ and WormPD™:: model organism volumes of the BioKnowledge™ Library, an integrated resource for protein information
YPD™, PombePD™ and WormPD™:: model organism volumes of the BioKnowledge™ Library, an integrated resource for protein information
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DOI：
10.1093/nar/29.1.75
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发表时间：
2001-01-01
影响因子：
14.9
通讯作者：
Garrels, JI
中科院分区：
文献类型：
--
作者：
Costanzo, MC;Crawford, ME;Garrels, JI
生物知识图书馆是一个关系数据库和网站（http:www.proteome.com），由从科学文献中收集的蛋白质特异性信息组成。网站上的每一份蛋白质报告都总结并展示了有关单个蛋白质的已发表信息，包括其生化功能、在细胞和整个生物体中的作用、定位、突变表型和遗传相互作用、调控、结构域和基序、与其他蛋白质的相互作用以及其他相关数据。本报告描述了生物知识库的四个物种特异性卷，涉及模式生物酿酒酵母菌（YPD）， PombePD （PombePD）和秀丽隐门线虫（WormPD），以及真菌病原体白色念珠菌（CalPD(TM)）。每个物种的蛋白质报告格式统一，易于检索和广泛的物种间交叉引用。本文讨论了这些综合整理的资源与其他物种蛋白质分析的相关性，并通过对与人类疾病相关的蛋白质相似的模式生物蛋白质的调查说明了这一点。
The BioKnowledge Library is a relational database and web site (http:www.proteome.com) composed of protein-specific information collected from the scientific literature. Each Protein Report on the web site summarizes and displays published information about a single protein, including its biochemical function, role in the cell and in the whole organism, localization, mutant phenotype and genetic interactions, regulation, domains and motifs, interactions with other proteins and other relevant data. This report describes four species-specific volumes of the BioKnowledge Library, concerned with the model organisms Saccharomyces cerevisiae (YPD), Schizosaccharomyces pombe (PombePD) and Caenorhabditis elegans (WormPD), and with the fungal pathogen Candida albicans (CalPD(TM)). Protein Reports of each species are unified in format, easily searchable and extensively cross-referenced between species. The relevance of these comprehensively curated resources to analysis of proteins in other species is discussed, and is illustrated by a survey of model organism proteins that have similarity to human proteins involved in disease.