Triclocarban enhances testosterone action: A new type of endocrine disruptor?
Triclocarban enhances testosterone action: A new type of endocrine disruptor?
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DOI：
10.1210/en.2007-1057
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发表时间：
2008-03-01
期刊：
影响因子：
4.8
通讯作者：
Lasley, Bill L.
中科院分区：
文献类型：
--
作者：
Chen, Jiangang;Ahn, Ki Chang;Lasley, Bill L.
许多外源物质与多种生物系统中的内分泌效应有关。这些关联通常发生在非类固醇小分子和类固醇受体信号系统之间。在本报告中，对个人护理产品中用作抗菌剂的常见成分三氯卡班（TCC；3,4,4'-三氯卡苯胺）进行了评估，发现它代表了一类新的内分泌干扰物质。基于细胞的雄激素受体介导的生物测定被用来证明TCC和其他具有相似结构的尿素化合物在单独测试时几乎没有或没有内分泌活性，可在体外增强睾酮（T）诱导的雄激素受体介导的转录活性。当在去势雄性大鼠的饮食中添加0.25% TCC并接受外源性睾酮治疗10天时，TCC的这种放大效应在体内也很明显。与单独 T 或 TCC 治疗相比，T+TCC 治疗后所有男性性附属器官的大小均显着增加。这里提供的数据表明，接触含有足够水平 TCC 的商业个人护理产品可能会放大内源激素的生物活性。
Many xenobiotics have been associated with endocrine effects in a wide range of biological systems. These associations are usually between small nonsteroid molecules and steroid receptor signaling systems. In this report, triclocarban (TCC; 3,4,4'-trichlorocarbanilide), a common ingredient in personal care products that is used as an antimicrobial agent was evaluated and found to represent a new category of endocrine-disrupting substance. A cell-based androgen receptor-mediated bioassay was used to demonstrate that TCC and other urea compounds with a similar structure, which have little or no endocrine activity when tested alone, act to enhance testosterone (T)-induced androgen receptor-mediated transcriptional activity in vitro. This amplification effect of TCC was also apparent in vivo when 0.25% TCC was added to the diet of castrated male rats that were supported by exogenous testosterone treatment for 10 d. All male sex accessory organs increased significantly in size after the T+TCC treatment, compared with T or TCC treatments alone. The data presented here suggest that the bioactivity of endogenous hormones may be amplified by exposure to commercial personal care products containing sufficient levels of TCC.