The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy
The Risk of Gallbladder Stone Formation Is Increased in Patients with Predialysis Chronic Kidney Disease but Not Those Undergoing Chronic Hemodialysis Therapy
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DOI：
10.1159/000199456
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发表时间：
2009-01-01
影响因子：
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通讯作者：
Gejyo, Fumitake
中科院分区：
文献类型：
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作者：
Kazama, Junichiro James;Kazama, Sakumi;Gejyo, Fumitake
背景：尚不清楚慢性肾脏病（CKD）患者胆囊结石（GBS）的患病率是否较高。方法：总共 398 名 CKD 患者，每个阶段有 5 个疾病阶段 [CKD1:26;CKD1:26]。 CKD2：52； CKD3：58； CKD4：48； CKD5:214 例，其中 61 例处于透析前，153 例处于透析中 (CKD5D)] 纳入本研究。超声检查发现GBS或有因GBS而接受胆囊切除史的患者被视为GBS患者。结果：与对照组5.9%的GBS患病率相比，CKD患者的GBS患病率随着疾病分期的进展而增加（CKD1：7.7%；CKD2：15.4%；CKD3：19.0%；CKD4：20.8%；CKD5透析前：21.3%；CKD5D：22.9%）。 CKD5 患者的患病率显着高于对照组。 CKD5 是 GBS 的一个危险因素，与年龄或性别无关。然而，在 CKD5D 患者中，GBS 患病率与血液透析治疗持续时间之间没有发现显着关系。年龄是透析前 CKD 患者中与 GBS 相关的唯一因素。结论：透析前 CKD 患者形成 GBS 的风险较高。尽管 CKD5D 患者的风险消失，但 GBS 的患病率仍显着高于对照人群。促进透析前 CKD 患者 GBS 形成和/或抑制 CKD5D 患者 GBS 形成的因素仍不清楚。版权所有 (C) 2009 S. Karger AG，巴塞尔
Background: It is unclear whether the prevalence of gallbladder stones (GBS) is higher in patients with chronic kidney disease (CKD). Methods: A total of 398 patients with CKD of each of the 5 disease stages [CKD1:26; CKD2:52; CKD3:58; CKD4:48; CKD5:214, of whom 61 were predialysis and 153 were on dialysis (CKD5D)] were included in this study. Those in whom GBS were detected by ultrasonographic examination or who had a history of cholecystectomy owing to GBS were considered GBS patients. Results: In comparison to the GBS prevalence of 5.9% in the control group, that in CKD patients increased with the advancement of the disease stage (CKD1: 7.7%; CKD2: 15.4%; CKD3: 19.0%; CKD4: 20.8%; CKD5 predialysis: 21.3%; CKD5D: 22.9%). The prevalence was significantly greater in CKD5 patients than in the control group. CKD5 is a risk factor for GBS independent of age or sex. However, no significant relationship was found between the prevalence of GBS and the duration of hemodialysis therapy in CKD5D patients. Age was the only factor that was associated with GBS in predialysis CKD patients. Conclusion: The risk of GBS formation was high in predialysis CKD patients. Although the risk disappeared in CKD5D patients, the prevalence of GBS was still significantly higher than in the control population. Factors that promote GBS formation in predialysis CKD patients and/or that inhibit GBS formation in CKD5D patients remain unknown. Copyright (C) 2009 S. Karger AG, Basel