Association of baseline platelet count with all-cause mortality after acute myocardial infarction
Association of baseline platelet count with all-cause mortality after acute myocardial infarction
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DOI：
10.1177/2048872620925257
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发表时间：
2020-05-14
影响因子：
4.1
通讯作者：
Seong, In-Whan
中科院分区：
文献类型：
--
作者：
Song, Pil Sang;Ahn, Kye Taek;Seong, In-Whan
BackgroundWe sought to evaluate baseline platelet count as a prognostic indicator in patients with acute myocardial infarction (AMI).MethodsData of 13,085 patients with AMI were retrieved from a prospective nationwide AMI registry from November 2011 to December 2015. Using Cox hazards models, cumulative risks for adverse outcomes were compared among patients with baseline platelet count of less than 150 K/mu L (lowest quartile), 150 to 249 K/mu L, 250 to 349 K/mu L (reference) and equal to or greater than 350 K/mu L (higher quartile). The primary outcome of interest was all-cause mortality. Secondary outcomes included myocardial infarction, re-hospitalisation for heart failure, and stroke.ResultsDuring a median follow-up of 2.1 years, a steep U-shaped association was observed for the occurrence of all-cause mortality (p for non-linearity = 75 years or patients with heart failure.ConclusionsIn patients with AMI, baseline platelet count demonstrated a U-shaped association with an increased risk of all-cause mortality at two years. If validated, these findings suggest that baseline platelet count could serve as a preferred prognostic marker in AMI due to its low cost and universal availability.
