One-Year Linear Trajectories of Symptoms, Physical Functioning, Cognitive Functioning, Emotional Well-being, and Spiritual Well-being Among Patients Receiving Dialysis.
One-Year Linear Trajectories of Symptoms, Physical Functioning, Cognitive Functioning, Emotional Well-being, and Spiritual Well-being Among Patients Receiving Dialysis.
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DOI：
10.1053/j.ajkd.2017.11.016
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Hladik GA
中科院分区：
文献类型：
--
作者：
Song MK;Paul S;Ward SE;Gilet CA;Hladik GA
本研究评价了透析患者中患者报告的生活质量维度的1年线性轨迹。纵向观察性研究从12家透析中心招募了227例患者。参与者每月完成一次长达一小时的访谈，持续12个月。每次访谈都包括患者报告的总体症状结局指标（埃德蒙顿症状评估系统），身体功能（日常生活活动/日常生活工具活动），认知功能（患者对自身功能量表的评估）、情绪健康（流行病学研究中心抑郁量表，状态焦虑量表，积极和消极情绪量表），慢性疾病治疗功能评估-精神健康量表（Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale）对于每个维度，使用线性和广义线性混合效应模型。随着时间的推移，五个维度的线性轨迹被联合建模为多变量结果。虽然维度分数每月波动很大，但总体症状，认知功能，情绪健康和精神健康随着时间的推移而改善。与年轻参与者相比，老年参与者在所有维度上的得分都更高（所有P值<0.05）。合并症评分越高，大多数维度的评分越差（所有P值均<0.01）。非白色参与者的精神幸福感比白色参与者更好（P<0.01）。聚类分析的维度得分揭示了两个独特的集群。组1的特征是在基线时几乎所有维度的评分都优于组2，并且随着时间的推移逐渐改善。研究在美国的一个地区进行，主要包括在所研究的生活质量维度中具有高水平功能的患者。多维患者报告的生活质量每月变化很大，无论总体轨迹是否随时间推移而改善或恶化。需要进一步的研究来确定将患者报告的结局指标纳入透析护理的最佳方法。
This study evaluated one-year linear trajectories of patient-reported dimensions of quality of life among patients on dialysis. Longitudinal observational study 227 patients recruited from 12 dialysis centers. Sociodemographic and clinical characteristics Participants completed an hour-long interview monthly for 12 months. Each interview included patient-reported outcome measures of overall symptoms (Edmonton Symptom Assessment System), physical functioning (Activities of Daily Living/Instrumental Activities of Daily Living), cognitive functioning (Patient’s Assessment of Own Functioning Inventory), emotional well-being (Center for Epidemiologic Studies Depression Scale, State Anxiety Inventory, Positive and Negative Affect Schedule), and spiritual well-being (Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale). For each dimension, linear and generalized linear mixed effects models were used. The linear trajectories of the five dimensions were jointly modeled as a multivariate outcome over time. Although the dimension scores fluctuated greatly from month to month, overall symptoms, cognitive functioning, emotional well-being, and spiritual well-being improved over time. Older compared to younger participants reported higher scores across all dimensions (all P values <0.05). Higher comorbidity scores were associated with worse scores in most dimensions (all P values <0.01). Non-white participants reported better spiritual well-being compared to their white counter parts (P<0.01). Clustering analysis of the dimension scores revealed two distinctive clusters. Cluster 1 was characterized by better scores than those of cluster 2 in nearly all dimensions at baseline and by gradual improvement over time. Study was conducted in a single region of the United States and included mostly patients with high levels of function across the dimensions of quality of life studied. Multidimensional patient-reported quality of life varies widely from month to month regardless of whether overall trajectories improve or worsen over time. Additional research is needed to identify the best approaches to incorporate patient-reported outcome measures into dialysis care.
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影响因子：
13.2
作者：
Plantinga, Laura C.;Johansen, Kirsten;Powe, Neil R.
通讯作者：
Powe, Neil R.
影响因子：
5.4
作者：
Greenhalgh, J;Long, AF;Flynn, R
通讯作者：
Flynn, R
影响因子：
11.3
作者：
Richardson-Vejlgaard, Randall;Dawes, Sharron;Heaton, Robert K.;Bell, Morris D.
通讯作者：
Bell, Morris D.
影响因子：
19.6
作者：
Davison, SN;Jhangri, GS;Johnson, JA
通讯作者：
Johnson, JA
DOI：
10.2147/ijnrd.s37766
发表时间：
2012
影响因子：
2
作者：
Braun L;Sood V;Hogue S;Lieberman B;Copley-Merriman C
通讯作者：
Copley-Merriman C