Racial differences in sleep-disordered breathing in African-Americans and Caucasian
Racial differences in sleep-disordered breathing in African-Americans and Caucasian
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DOI：
10.1164/ajrccm.155.1.9001310
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发表时间：
1997-01-01
影响因子：
24.7
通讯作者：
Spry, K
中科院分区：
文献类型：
--
作者：
Redline, S;Tishler, PV;Spry, K
在这个睡眠呼吸障碍（SDB）的病例对照家庭研究中，我们描述了SDB和SDB危险因素在非洲裔美国人和白人中的分布。共有225名非洲裔美国人和622名白人，年龄2至86岁，招募为已知睡眠呼吸暂停个体的家庭成员（85个索引家庭）或作为邻居对照家庭成员（63个家庭），进行了一项夜间家庭睡眠研究，问卷调查和身体测量。1例受试者接受头影测量。结果的措施是呼吸紊乱指数（RDI）和一个二元变量，表明存在增加的呼吸暂停活动（IAA）。在两个种族中，RDI（对数转换）与年龄和年龄之间存在很强的相关性（2）。非裔美国人SDB患者比白人SDB患者更年轻（37.2 +/- 19.5岁对45.6 +/- 18.7岁，p < 0.01）。在小于或等于25岁的受试者中，非裔美国人的RDI水平和IAA患病率较高（比值比，经肥胖、性别、先证者抽样和家族聚集性调整后，1.88，1.03至3.52，95% CI）。在这个年龄组中，RDI和年龄之间的关系也存在种族差异（RDI-年龄相互作用p < 0.001）。这表明年轻的非洲裔美国人可能会增加睡眠呼吸暂停的风险。
In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians. A total of 225 African-Americans and 622 Caucasians, ages 2 to 86 yr, recruited as members of families with an individual with known sleep apnea (85 index families) or as members of neighborhood control families (63 families) were studied with an overnight home sleep-study, questionnaires, and physical measurements. A subsampre underwent cephalometry. Outcome measures were the respiratory disturbance index (RDI) and a binary variable indicating the presence of increased apneic activity (IAA). In both races, a strong relationship was demonstrated between the (log transformed) RDI and age and age(2). African-Americans with SDB were younger than Caucasians with SDB (37.2 +/- 19.5 versus 45.6 +/- 18.7 yr, p < 0.01). In subjects less than or equal to 25 yr, RDI level and IAA prevalence were higher in African-Americans (odds ratio, adjusted for obesity, sex, proband sampling, and familial clustering, 1.88, 1.03 to 3.52, 95% CI). In this age group, racial differences also were observed in the relationship between RDI and age (p < 0.001 for the RDI-age interaction). This suggests that young African-Americans may be at increased risk for sleep apnea.