Effect of Isoniazid Therapy for Latent TB Infection on QuantiFERON-TB Gold In-Tube Responses in Adults With Positive Tuberculin Skin Test Results in a High TB Incidence Area
Effect of Isoniazid Therapy for Latent TB Infection on QuantiFERON-TB Gold In-Tube Responses in Adults With Positive Tuberculin Skin Test Results in a High TB Incidence Area
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DOI：
10.1378/chest.13-1232
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发表时间：
2014-03-01
期刊：
影响因子：
9.6
通讯作者：
Hatherill, Mark
中科院分区：
文献类型：
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作者：
Johnson, John L.;Geldenhuys, Hendrik;Hatherill, Mark
背景：T 细胞干扰素 g 释放测定 (IGRA) 用于诊断结核分枝杆菌感染，并且可能成为临床试验、感染控制单位和结核病项目对潜伏性结核感染治疗反应的有用生物标志物。方法：这项研究是对 82 名 HIV 血清阴性和结核菌素皮试结果阳性的健康南非成年人进行的 IGRA 反应的前瞻性、对照亚组研究，随机分配接受 6 个月每日异烟肼治疗在临床试验中重新接种卡介苗之前进行预防性治疗 (IPT) 或观察。 QuantiFERON-TB Gold In-Tube (QFT-GIT) 测定用于测量基线时以及 IPT 或观察后对分枝杆菌抗原的干扰素-γ (IFN-gamma) 反应。结果：IFN-gamma 水平在基线和 IPT 结束之间下降（符号秩检验 P）
Background: T-cell interferon-g release assays (IGRAs) are used in the diagnosis of Mycobacterium tuberculosis infection and could be useful biomarkers of response to treatment of latent TB infection for clinical trials, infection control units, and TB programs.Methods: This investigation was a prospective, controlled substudy of IGRA responses in 82 healthy South African adults with HIV seronegative and positive tuberculin skin test results randomly assigned to treatment with 6 months of daily isoniazid preventive therapy (IPT) or observation before Bacillus Calmette-Guerin revaccination in a clinical trial. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay was used to measure interferon-gamma (IFN-gamma) response to mycobacterial antigens at baseline and after IPT or observation.Results: IFN-gamma levels declined between baseline and the end of IPT (signed rank test P