The challenge of evolving stable polyploidy: could an increase in "crossover interference distance" play a central role?
The challenge of evolving stable polyploidy: could an increase in "crossover interference distance" play a central role?
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DOI：
10.1007/s00412-015-0571-4
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发表时间：
2016-06
期刊：
影响因子：
1.6
通讯作者：
Kleckner N
中科院分区：
文献类型：
--
作者：
Bomblies K;Jones G;Franklin C;Zickler D;Kleckner N
全基因组复制是许多高度进化的生物，特别是植物的一个显著特征。当复制发生在物种内时，它们产生包含每个染色体的多个相同或非常相似的拷贝的基因组（“同源多倍体”）。这些基因组在减数分裂过程中面临着特殊的挑战，减数分裂是一种特殊的细胞程序，是有性生殖配子形成的基础。新形成的（新）-同源四倍体和完全进化的同源四倍体之间的比较表明，这些挑战得到解决的交叉重组事件的位置上的特定限制，因此，交叉的位置，其中管理的同源物的分离在第一次减数分裂。我们提出，这些更有效的交叉模式的演变中的一个关键特征是减数分裂交叉干扰，这在交叉定位中起着核心作用的有效距离的增加。我们讨论了在几种生物中的发现，包括最近在拟南芥中发现的相关基因，支持这一假设。本文的在线版本（doi：10.1007/s 00412 -015-0571-4）包含补充材料，可供授权用户使用。
Whole genome duplication is a prominent feature of many highly evolved organisms, especially plants. When duplications occur within species, they yield genomes comprising multiple identical or very similar copies of each chromosome (“autopolyploids”). Such genomes face special challenges during meiosis, the specialized cellular program that underlies gamete formation for sexual reproduction. Comparisons between newly formed (neo)-autotetraploids and fully evolved autotetraploids suggest that these challenges are solved by specific restrictions on the positions of crossover recombination events and, thus, the positions of chiasmata, which govern the segregation of homologs at the first meiotic division. We propose that a critical feature in the evolution of these more effective chiasma patterns is an increase in the effective distance of meiotic crossover interference, which plays a central role in crossover positioning. We discuss the findings in several organisms, including the recent identification of relevant genes in Arabidopsis arenosa, that support this hypothesis. The online version of this article (doi:10.1007/s00412-015-0571-4) contains supplementary material, which is available to authorized users.