Disrupted relationship between "resting state" connectivity and task-evoked activity during social perception in schizophrenia
Disrupted relationship between "resting state" connectivity and task-evoked activity during social perception in schizophrenia
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DOI：
10.1016/j.schres.2017.07.020
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发表时间：
2018-03-01
影响因子：
4.5
通讯作者：
Northoff, Georg
中科院分区：
文献类型：
--
作者：
Ebisch, Sjoerd J. H.;Gallese, Vittorio;Northoff, Georg
精神分裂症被描述为一种自我失调，而社会缺陷是这种疾病的主要特征。在精神分裂症中，参与自我相关处理的大脑网络的“静息状态”活动的变化一直被报道，但它们对社会感知缺陷的意义仍然知之甚少。在这里，我们采用了一种新的方法，调查任务诱发的神经活动在社会知觉和自我相关的大脑网络的功能组织在“休息状态”之间的关系。“静息状态”功能磁共振成像与任务相关的功能磁共振成像结合使用的社会知觉实验。包括21名健康对照参与者（HC）和21名诊断为精神分裂症（SCH）的门诊患者。年龄、智商、受教育程度和性别在两组间无显著差异。结果表明，减少“静息状态”的功能连接腹内侧前额叶皮层和背后扣带皮层在SCH相比，HC。在社会知觉过程中，背侧后扣带皮层的神经活动和行为数据表明SCH中社会刺激的一致性编码受损。在HC中，“静息状态”期间背侧后扣带皮层的任务诱发活动与背侧后扣带皮层-腹内侧前额叶皮层的功能连接共变，任务诱发活动也与SCH中的阴性症状相关。这些初步研究结果显示，精神分裂症患者自我相关脑网络的“静息状态”功能对社会感知测量的预测被破坏，提供了重要的洞察力在自我和社会赤字之间的假设联系。他们还阐明了“休息状态”变化对社会感知等任务的意义。(c)2017爱思唯尔B. V.保留所有权利。
Schizophrenia has been described as a self-disorder, whereas social deficits are key features of the illness. Changes in "resting state" activity of brain networks involved in self-related processing have been consistently reported in schizophrenia, but their meaning for social perception deficits remains poorly understood. Here, we applied a novel approach investigating the relationship between task-evoked neural activity during social perception and functional organization of self-related brain networks during a "resting state"."Resting state" functional MRI was combined with task-related functional MRI using a social perception experiment. Twenty-one healthy control participants (HC) and 21 out-patients with a diagnosis of schizophrenia (SCH) were included. There were no significant differences concerning age, IQ, education and gender between the groups. Results showed reduced "resting state" functional connectivity between ventromedial prefrontal cortex and dorsal posterior cingulate cortex in SCH, compared to HC. During social perception, neural activity in dorsal posterior cingulate cortex and behavioral data indicated impaired congruence coding of social stimuli in SCH. Task-evoked activity during social perception in dorsal posterior cingulate cortex co-varied with dorsal posterior cingulate cortex-ventromedial prefrontal cortex functional connectivity during a "resting state" in HC, but not in SCH. Task-evoked activity also correlated with negative symptoms in SCH.These preliminary findings, showing disrupted prediction of social perception measures by "resting state" functioning of self-related brain networks in schizophrenia, provide important insight in the hypothesized link between self and social deficits. They also shed light on the meaning of "resting state" changes for tasks such as social perception. (c) 2017 Elsevier B.V. All rights reserved.