Mechanical contribution of lamellar and interlamellar elastin along the mouse aorta
Mechanical contribution of lamellar and interlamellar elastin along the mouse aorta
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DOI：
10.1016/j.jbiomech.2015.08.004
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发表时间：
2015-10-15
影响因子：
2.4
通讯作者：
Shadwick, R. E.
中科院分区：
文献类型：
--
作者：
Clark, T. E.;Lillie, M. A.;Shadwick, R. E.
主动脉弹性蛋白的机械性能各不相同的区域，但这种变化的微观结构的基础是未知的。本研究的目的是确定板层和层间弹性蛋白的相对贡献，以周向负荷轴承在小鼠的胸部和腹部的椎骨。新鲜和高压灭菌的主动脉样品的单轴试验中开发的力与弹性蛋白含量和形态从组织学和多光子激光扫描显微镜获得。高压灭菌会使许多层间弹性蛋白丧失机械功能。在高压灭菌的组织中，每单位样本宽度的力与板层弹性蛋白含量相关（P
The mechanical properties of aortic elastin vary regionally, but the microstructural basis for this variation is unknown. This study was designed to identify the relative contributions of lamellar and interlamellar elastin to circumferential load bearing in the mouse thoracic and abdominal aortas. Forces developed in uniaxial tests of samples of fresh and autoclaved aorta were correlated with elastin content and morphology obtained from histology and multiphoton laser scanning microscopy. Autoclaving should render much of the interlamellar elastin mechanically incompetent. In autoclaved tissue force per unit sample width correlated with lamellar elastin content (P