Neurological complications of sickle cell anemia.
Neurological complications of sickle cell anemia.
复制标题
镰状细胞性贫血的神经系统并发症。
DOI：
10.1097/00043426-198224000-00006
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Lusher,JM
中科院分区：
文献类型：
--
作者：
Sarnaik,SA;Lusher,JM
镰状细胞血红蛋白病可引起多种神经系统并发症。最引人注目和最常见的是脑梗死。这也是最具破坏性的。由于未经治疗的患者复发率高，脑梗死是最令人衰弱的神经系统并发症。在不同的报告中，观察到的频率从6%到高达34%不等。讨论了其发病机制、临床特征和人口统计学。诊断程序应包括脊椎穿刺，以排除潜在的可治疗的病变。在某些情况下，CT扫描和脑血管造影也可能有帮助。输血治疗仍然是脑梗死急性期的主要治疗手段。有相当多的证据表明，长期输血计划是有效的预防复发。
A variety of neurological complications occur with sickle cell hemoglobinopathy. The most striking and most common is cerebral infarction. It is also the most devastating. Because of the high recurrence rate in untreated patients, cerebral infarction is the most debilitating neurological complication. The observed frequency varies from 6% to as high as 34% in different reports. The pathogenesis, clinical features, and demography are discussed. Diagnostic procedures should include a spinal tap to rule out potentially treatable lesions. CT scan and cerebral angiography may also be helpful in certain cases. Transfusion therapy remains the mainstay of management in the acute phase of cerebral infarction. There is considerable evidence to indicate that long-term transfusion programs are effective in the prevention of recurrences.