Branched mitochondrial electron transport in the animalia: Presence of alternative oxidase in several animal phyla
Branched mitochondrial electron transport in the animalia: Presence of alternative oxidase in several animal phyla
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DOI：
10.1080/1521-6540400000876
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发表时间：
2004-06-01
期刊：
影响因子：
4.6
通讯作者：
Vanlerberghe, GC
中科院分区：
文献类型：
--
作者：
McDonald, AE;Vanlerberghe, GC
大多数真核生物的线粒体具有多个电子传递组件，增加了电子的进入点和/或出入点，从而使呼吸链具有分支性质。在植物和许多其他生物中，一个突出的例子是替代氧化酶，它是呼吸链中的一个非能量守恒的分支，是另一个用于电子退出的末端氧化酶。我们的基因组数据库搜索现在发现了来自三个不同门(软体动物门、线虫门和脊索动物门)的四个动物物种中存在替代氧化酶，这与动物中抗氰化物呼吸的频繁报道一致。在海鞘和长牡蛎中，交替氧化酶在几个不同的组织中表达。系统发育分析与动物蛋白质起源于垂直遗传是一致的。我们假设交替氧化酶可能在动物中广泛存在，并讨论了这种分支呼吸链的一些潜在作用(S)。
The mitochondrion of most eukaryotes has multiple electron transport components that increase the points of entry and/or exit of electrons, thus giving a branched nature to the respiratory chain. In plants and many other organisms, a prominent example is alternative oxidase, a non-energy conserving branch in the respiratory chain and an additional terminal oxidase for the exit of electrons. Our genome database searches have now revealed the presence of alternative oxidase in four animal species from three different phyla ( Mollusca, Nematoda and Chordata), consistent with frequent reports of cyanide-resistant respiration in the Animalia. In Ciona intestinalis and Crassostrea gigas, alternative oxidase is expressed in several different tissues. Phylogenetic analysis is consistent with the animal proteins having originated by vertical inheritance. We hypothesize that alternative oxidase is likely widespread in the Animalia and discuss some of the potential role(s) for such a branched respiratory chain.